ID A0A5B9NH88_9CAUD Unreviewed; 296 AA.
AC A0A5B9NH88;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=MARVELLAND_43 {ECO:0000313|EMBL:QEG13574.1};
OS Bacillus phage vB_BspM_MarvelLand.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Herelleviridae; Bastillevirinae; Tsarbombavirus.
OX NCBI_TaxID=2591380 {ECO:0000313|EMBL:QEG13574.1, ECO:0000313|Proteomes:UP000322625};
RN [1] {ECO:0000313|EMBL:QEG13574.1, ECO:0000313|Proteomes:UP000322625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Handoko Y.A., Wardani A.K., Widjanarko S.B., Sharma R., Flor S.,
RA Grose J.H.;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MN013089; QEG13574.1; -; Genomic_DNA.
DR Proteomes; UP000322625; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..289
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 296 AA; 33772 MW; A7440576EC6E738A CRC64;
MTIDNNVDSQ YLELAAKVLK EGNRKGDRTG TGTRSLFGAQ MRFDLSKGFP MLTTKKLPFR
IIVEELLWFI SGSTNMKDLL DKNVHIWDDD AYRWYKELGR PLPKKEFFDC IKECGFDLGA
IYGAQWRNWN NEGIDQLKNV IEEIKKNPDS RRLLVLAFNP SVIGKVALPP CHYVFQFYVA
DGKLSCMFTM RSNDVFLGLP FNIASYALLV HIIAKMTGLA VGELVYSCGD VHVYNNHVEQ
LELQMTREAK PLPTLKVNAV HENIEDYTID DFELIGYDPH PVIKGKVSVG LKEEEK
//
