ID A0A5B9Y2P3_9MOLU Unreviewed; 310 AA.
AC A0A5B9Y2P3;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=HPr kinase/phosphorylase {ECO:0000313|EMBL:QEH61300.1};
GN Name=hprK {ECO:0000313|EMBL:QEH61300.1};
GN ORFNames=SCHIN_v1c01020 {ECO:0000313|EMBL:QEH61300.1};
OS Spiroplasma chinense.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=216932 {ECO:0000313|EMBL:QEH61300.1, ECO:0000313|Proteomes:UP000323144};
RN [1] {ECO:0000313|EMBL:QEH61300.1, ECO:0000313|Proteomes:UP000323144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCH {ECO:0000313|EMBL:QEH61300.1,
RC ECO:0000313|Proteomes:UP000323144};
RA Shen H.-Y., Lin Y.-C., Chou L., Kuo C.-H.;
RT "Complete genome sequence of Spiroplasma chinense CCH (DSM 19755).";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-
CC serine + ADP + H(+); Xref=Rhea:RHEA:46600, Rhea:RHEA-COMP:11602,
CC Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001120};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr
CC protein]-L-serine + diphosphate; Xref=Rhea:RHEA:46604, Rhea:RHEA-
CC COMP:11602, Rhea:RHEA-COMP:11603, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; Evidence={ECO:0000256|ARBA:ARBA00001319};
CC -!- SIMILARITY: Belongs to the HPrK/P family.
CC {ECO:0000256|ARBA:ARBA00006883}.
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DR EMBL; CP043026; QEH61300.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B9Y2P3; -.
DR KEGG; schi:SCHIN_v1c01020; -.
DR Proteomes; UP000323144; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006109; P:regulation of carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd01918; HprK_C; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003755; HPr(Ser)_kin/Pase.
DR InterPro; IPR011104; Hpr_kin/Pase_C.
DR InterPro; IPR011126; Hpr_kin/Pase_Hpr_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR NCBIfam; TIGR00679; hpr-ser; 1.
DR PANTHER; PTHR30305:SF1; HPR KINASE_PHOSPHORYLASE; 1.
DR PANTHER; PTHR30305; UNCHARACTERIZED; 1.
DR Pfam; PF07475; Hpr_kinase_C; 1.
DR Pfam; PF02603; Hpr_kinase_N; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR SUPFAM; SSF53795; PEP carboxykinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:QEH61300.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000323144};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..124
FT /note="HPr(Ser) kinase/phosphorylase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02603"
FT DOMAIN 131..292
FT /note="HPr kinase/phosphorylase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07475"
SQ SEQUENCE 310 AA; 35086 MW; 50B17CF681A45E50 CRC64;
MKKLTLNKII KAFDLEVVCG KDKIDNVIEV YGLNRAGLEL TGYYEKGEKS HRLILMSTKE
YSYIMNFDEE VRRERYKNLL QKNIPGLITT AKFRDELLFK VGEELGMPIL RTAAESTSDF
TKDVLDLFDN YFAPQIELHA SFVNIFGKGV LLVGESGIGK SELAVDLVKQ NHLFVGDDRI
VVTKKAGYLY GKSHEILKNL VEVRGIGIID ISKTNGYKVI MEESPVDMVI ELSMFKKDGV
DDSERLGRNF GTYSILGMQL PYIKIPVASG RNIQTIIETA VAKLKITQSG LYEDDTKLLT
DRFREFAENE
//
