ID A0A5C1YI05_9MICO Unreviewed; 314 AA.
AC A0A5C1YI05;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=FLP10_12015 {ECO:0000313|EMBL:QEO15060.1};
OS Agromyces intestinalis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agromyces.
OX NCBI_TaxID=2592652 {ECO:0000313|EMBL:QEO15060.1, ECO:0000313|Proteomes:UP000324678};
RN [1] {ECO:0000313|EMBL:QEO15060.1, ECO:0000313|Proteomes:UP000324678}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KACC 19306 {ECO:0000313|EMBL:QEO15060.1,
RC ECO:0000313|Proteomes:UP000324678};
RA Heo J., Kim S.-J., Kim J.-S., Hong S.-B., Kwon S.-W.;
RT "Genome sequencing of strain KACC 19306.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP043505; QEO15060.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C1YI05; -.
DR OrthoDB; 9774633at2; -.
DR Proteomes; UP000324678; Chromosome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000324678};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 56..221
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 314 AA; 35521 MW; DD9DC4CA810B54F4 CRC64;
MLLVEEDSLD DVLQVVFKHL LESGKQIAPS KGSALEQLGA AIELRNPLAR LSRSQRRSPI
FSALGEWLWY LSGTDEVAPI VHYIPMYERF AVAGRVEGAY GPRLFGDGQR LMEVVKRLRS
KQDSRQAVIQ LFEHSDLSNQ KDIPCTTTLQ FFLRDQALHL AVTMRSNDAY RGLPHDVFAF
TMIQEVVARC LGTEVGTYMH FVGSLHLYDS DAAAATEFLE EGWHHLKPMP AMPKEDPEGG
LRWLLGVEEQ IRSGDSKAPG PADFGTHPYW DDLGRLLLAH RATSESDFVR IRESLDDEFY
AIYITDKHAR LDKH
//
