ID A0A5C3E076_9BASI Unreviewed; 1008 AA.
AC A0A5C3E076;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=UTRI_03371 {ECO:0000313|EMBL:SPO24103.1};
OS Ustilago trichophora.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=86804 {ECO:0000313|EMBL:SPO24103.1, ECO:0000313|Proteomes:UP000324022};
RN [1] {ECO:0000313|EMBL:SPO24103.1, ECO:0000313|Proteomes:UP000324022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC100155 {ECO:0000313|EMBL:SPO24103.1,
RC ECO:0000313|Proteomes:UP000324022};
RA Guldener U.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; OOIN01000007; SPO24103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C3E076; -.
DR Proteomes; UP000324022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000324022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 15..47
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 69..103
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 128..169
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..201
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 733..950
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 604..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1008 AA; 109982 MW; 874758F4087BA33B CRC64;
MSIILPDWVT HHNEEKKGKS TIFSVAVHPD SSRLATAGLD TKIRIWSTAA ILNETHEKDS
NAHRLLSTLS RHTGSVLVVR WANSGRFLAS GSDDTVALIW DLDPSGMGGG SFGSSEVNIE
SWRPYRRLAG HESDVVDLAW AEDDEFIATV GLDSKVFIWS GATFERLRTI DAHQGFVKGV
VFDPLGQYLA TASDDKTVKV WRTSDWGLEQ SITDPFLTSP STAFFRRPSW SPDGSLLLCA
NAMSGPVFVA SVSKRNVWVG DIFFVGHENA VVVTAFSPKI FVGFDGGTHS CVVALGSLDQ
SVSIWVTGLE SPVLVARDVF ERQVMDLSWS ADGYTLYGCS SDGTVAVFQL CPELISDALS
ADRLEQSRAK HGVKRIRNAL ANSNAALTVG TSDRPNVLQP RKAGQPQAAR LSVAPVPVAG
SVAPVRPAAT KPERLQQTIT ITKDGKRRIR PTLIGDDLAP APAPAAHYAP EPATTSSSHG
SRPAIQHHQL PAMREAVGGT TTDGFGAGQN VNGIHTNIAN GSFHGAAATV PASTPALAIP
AGAAVSMMPY VPVGLPFGIM PEGASPEDMM QFWTEFQQRF MRGKKRKAEE VETDSEDIEP
IGKLQKGKTR ADIGRTLGGE TPRDPPGPKK VLREALAGAS GIVENGVRKG VHLVVPETSS
IYRRDEDGIS IEIRNFDESR PTEIARLDPS DKDRVLWIDF SPTAATLATT SSFFSAVALE
DSTVLIYSAR GRRIGNLLLD SACYRLESNG VILMAVTVSG LMYRWNIRTD REIHRPVSVL
NLLGDPENLF SMAVHANGAP IVVLHTEKAY TFDDNKLGWV CISDGWWAEH SEAWDGRTRS
RGSEASIRDP VRAIEAEINT MYVRRVHGDN QVGAQEESDD DETPPVEMSV PEDKKSDFVI
AVTLRHLEAR MLAATILDSA NEYKNYLMAY AKRIAEEGIK NQAEDLIKSL IGPIYYKPEK
DQEQAWEPMI LGFEKRHLCS QVLQILARPR NLTSLVQPYQ EILANMKA
//
