ID A0A5C3NF31_9AGAM Unreviewed; 1013 AA.
AC A0A5C3NF31;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Rad4-domain-containing protein {ECO:0000313|EMBL:TFK52131.1};
GN ORFNames=OE88DRAFT_1657189 {ECO:0000313|EMBL:TFK52131.1};
OS Heliocybe sulcata.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Heliocybe.
OX NCBI_TaxID=5364 {ECO:0000313|EMBL:TFK52131.1, ECO:0000313|Proteomes:UP000305948};
RN [1] {ECO:0000313|EMBL:TFK52131.1, ECO:0000313|Proteomes:UP000305948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OMC1185 {ECO:0000313|EMBL:TFK52131.1,
RC ECO:0000313|Proteomes:UP000305948};
RX PubMed=30886374; DOI=.1038/s41559-019-0834-1;
RA Varga T., Krizsan K., Foldi C., Dima B., Sanchez-Garcia M.,
RA Sanchez-Ramirez S., Szollosi G.J., Szarkandi J.G., Papp V., Albert L.,
RA Andreopoulos W., Angelini C., Antonin V., Barry K.W., Bougher N.L.,
RA Buchanan P., Buyck B., Bense V., Catcheside P., Chovatia M., Cooper J.,
RA Damon W., Desjardin D., Finy P., Geml J., Haridas S., Hughes K., Justo A.,
RA Karasinski D., Kautmanova I., Kiss B., Kocsube S., Kotiranta H.,
RA LaButti K.M., Lechner B.E., Liimatainen K., Lipzen A., Lukacs Z.,
RA Mihaltcheva S., Morgado L.N., Niskanen T., Noordeloos M.E., Ohm R.A.,
RA Ortiz-Santana B., Ovrebo C., Racz N., Riley R., Savchenko A., Shiryaev A.,
RA Soop K., Spirin V., Szebenyi C., Tomsovsky M., Tulloss R.E., Uehling J.,
RA Grigoriev I.V., Vagvolgyi C., Papp T., Martin F.M., Miettinen O.,
RA Hibbett D.S., Nagy L.G.;
RT "Megaphylogeny resolves global patterns of mushroom evolution.";
RL Nat. Ecol. Evol. 3:668-678(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; ML213509; TFK52131.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C3NF31; -.
DR STRING; 5364.A0A5C3NF31; -.
DR Proteomes; UP000305948; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000305948}.
FT DOMAIN 482..532
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 534..632
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 639..713
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..952
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 112524 MW; 77D285452E8293B9 CRC64;
MDGDRSPGEN SKGIEITLKS AKRKDKDNEK EAASQKAKQI QATRLARIRC HKIHTVALLA
SAAHRNAWIN DPLLHARILS IVPMHLQQPL SSPPGKRAVP SQAQRGRMFQ HAVEALVEWW
TAYFAVDGVG VRRWSYEEVR RVLDAYPLKK PETQDNSLPP IDQPEIKLSR HVLSLLSTEP
PLASESKSLQ KHLLMQRGSR DVSALLFTAL CRALGVPARL VVSLQSVGWW GDKPKPKKKG
GKGKGKAEEP ADEEEDDMEE VAIPKPLTPQ RDVKGKGKAK DSFPGNGEML DGGYIPADDS
KGKGKGKAKP VIKLRKSKAG GRRLNESPPA PRRPSTGPYL SAHPDPLDTP PILWTEVFSR
PDGVWMPVDP VRGTVNKRQQ FDPEWEVQKR GGKRKEEANR MVYVVGFEED GYAKDVTPRY
AANFLSRVSL VQGAAATSEL GASSSSAADR RKWWDRVLGM VKRPYVLNRD EIEDESFREL
LRREGMPSSV AGFKGHELYV LERHLKQTET IYPLEEIGRF RGEPVYSRSN VVELKTAENW
MRRGRAVKAG EQPLKTVKVK ASTINRRREL EMFGGGDGRA DTGKGRDGDA EDIENGLEIQ
LNGDLPGQRT REEEGLMQGL YAEFQTEVYK PPPVVNGKVP KNNFGNIDLY VPSMLPMGAV
HAPFKGAAKV ARTLGFDYAE AVTGFEFRKR RATPIITGVV VAAENEAALL EAYWEMERDA
EEKRQAKRHE QVLKRWTRLI QGLRIRDRLK RQYTDAGQIA STSKRDDEGN EPEKVGQEEE
REAFVEPGGY LTAVDDIVRP FALPRYQHVA FESAAPSRRS SPGPTNGAEE PSTSDHVTPL
TMDSVDDDIL DEEMEEVQVP QSVLSGIPKT MAELAEASAR RTQINTVNAD IAPQAIPIPS
ATTPSAQRRS GRTSRTNSTP GTLSSSTGGL NTTARNGRRK RTREDVSDSE EQAAKSAGES
SPNKRAKTKK SIPVVSATPV RSDRVLRTRK TKTSTELEEE RERELAYRRA VAE
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