ID A0A5C4M124_9PSEU Unreviewed; 1197 AA.
AC A0A5C4M124;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=5-oxoprolinase {ECO:0000313|EMBL:TNC24201.1};
GN ORFNames=FG385_19305 {ECO:0000313|EMBL:TNC24201.1};
OS Amycolatopsis alkalitolerans.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=2547244 {ECO:0000313|EMBL:TNC24201.1, ECO:0000313|Proteomes:UP000305546};
RN [1] {ECO:0000313|EMBL:TNC24201.1, ECO:0000313|Proteomes:UP000305546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SYSUP0005 {ECO:0000313|EMBL:TNC24201.1,
RC ECO:0000313|Proteomes:UP000305546};
RA Narsing Rao M.P., Li W.J.;
RT "Amycolatopsis alkalitolerans sp. nov., isolated from Gastrodia elata
RT Blume.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the oxoprolinase family.
CC {ECO:0000256|ARBA:ARBA00010403}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TNC24201.1}.
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DR EMBL; VDFW01000016; TNC24201.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C4M124; -.
DR OrthoDB; 9768323at2; -.
DR Proteomes; UP000305546; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR InterPro; IPR049517; ACX-like_C.
DR InterPro; IPR008040; Hydant_A_N.
DR InterPro; IPR002821; Hydantoinase_A.
DR InterPro; IPR003692; Hydantoinase_B.
DR InterPro; IPR045079; Oxoprolinase_fam.
DR PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR PANTHER; PTHR11365:SF23; HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF19278; Hydant_A_C; 1.
DR Pfam; PF05378; Hydant_A_N; 1.
DR Pfam; PF01968; Hydantoinase_A; 1.
DR Pfam; PF02538; Hydantoinase_B; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000305546}.
FT DOMAIN 8..187
FT /note="Hydantoinase/oxoprolinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF05378"
FT DOMAIN 206..493
FT /note="Hydantoinase A/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF01968"
FT DOMAIN 510..665
FT /note="Acetophenone carboxylase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19278"
FT DOMAIN 689..1196
FT /note="Hydantoinase B/oxoprolinase"
FT /evidence="ECO:0000259|Pfam:PF02538"
SQ SEQUENCE 1197 AA; 127819 MW; F9B1373EFE323542 CRC64;
MPMTRWQFWV DRGGTFTDIV ARRPDGGLVS HKLLSENPAR YRDAAVAGIR ELLGVPRGEA
VPAEQVEAVR MGTTVATNAL LERKGERTVL VVTRGFRDAL RIAYQNRPRI FDRHIVLPDM
LYDQVIEVDE RLSADGKVLR PLELDKAAGD LRGAYESGIG SIAIVLMHSH LHPDHERRLG
ELAREIGFTQ VSLSSEVSPL MKLVPRGDTT VVDAYLSPVL RRYVDQVADQ LSGVRLAFMQ
SNGGLAEARH FRGKDAILSG PAGGIVGMVR MSALAGFDHV IGFDMGGTST DVSHYAGEYE
RVFMAQVAGV RLRAPMLDIH TVAAGGGSIL HFDGSRYRVG PDSAGANPGP ASYRGGGPLT
VTDANVMLGR IQPAHFPAVF GPDGDQPLEA GLVREKFTEL AAEIRARTGD DRTPEQVAEG
FLRIAVANMA NAVKKISVQK GHDVTRYVLT TFGGAGGQHA CAVADSLGIP TVLVPPMAGV
LSALGIGLAD TTSIRQQSVI ARLEPGTLGT LEEVAGRLTK QTTAELLDQG VAAERIRVVR
RAQLRYDGTD TVVPVTLGGF DEMVAEFEAA YRTTYSFLMD RPLIVEAIAV EATGLTEQPD
LSPLGEHDGE AGPVDTVRLY SGGTWHEAPL YQRERMRPAD TVTGPAIIAE ANATTMVDEG
WQAKLNAGGH LILDRVEARA GAGATTKADP VLLEIFNNLF MSIAEQMGTR LEATSQSVNI
RERLDFSCAL FDPDGNLVAN APHIPVHLGS MGAGVKEVVR RRAGRMKRGD VYAVNDPYHG
GTHLPDVTVI TPVFSSDSEE ILFYVASRGH HAEIGGITPG SMPANSAHLD EEGVLFDNFL
LAEDGRFLEA ETRELLLGAR YPSRNADMNL ADLRAQVAAN AKGVDEVGKM IGLFGLDVVQ
AYMRHVQDNA EDAVRRVIGT LSDGEYRYEM DSGAGIAVKI TVDRAARSAT VDFTGTSPQL
ATNFNAPSSV ATAAVLYVFR TLVADEIPLN DGCLRPLKIV IPAGTMLSPE YPAAVVAGNV
ETSQAITGAL FAALGVQAEG AGTMNNLTFG NERHQYYETL GSGSGAGDGF AGASVVQTHM
TNSRLTDPEV LEWRFPVLLK EFSVRHGSGG RGTWAGGDGA VRRLEFLEPM TASTLSGHRR
IPPYGMAGGR PGALGHNRVH RADGTVTELA GADSVDLRPG DVLEIETPGG GGYGTPE
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