ID   A0A5C4WQ27_9ACTN        Unreviewed;       297 AA.
AC   A0A5C4WQ27;
DT   13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Dihydrodipicolinate synthase family protein {ECO:0000313|EMBL:KAB8195090.1};
GN   ORFNames=FH608_011875 {ECO:0000313|EMBL:KAB8195090.1};
OS   Nonomuraea phyllanthi.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2219224 {ECO:0000313|EMBL:KAB8195090.1, ECO:0000313|Proteomes:UP000312512};
RN   [1] {ECO:0000313|EMBL:KAB8195090.1, ECO:0000313|Proteomes:UP000312512}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA1-10 {ECO:0000313|EMBL:KAB8195090.1,
RC   ECO:0000313|Proteomes:UP000312512};
RA   Klykleung N., Tanasupawat S.;
RT   "Nonomuraea sp. nov., isolated from Phyllanthus amarus.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAB8195090.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; VDLX02000004; KAB8195090.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5C4WQ27; -.
DR   OrthoDB; 9778880at2; -.
DR   Proteomes; UP000312512; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000312512}.
FT   ACT_SITE        137
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         206
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   297 AA;  31949 MW;  4394D50F52DEC505 CRC64;
     MENRSKAWHG VMVATALPLR DDLSVDYDAY AEHCRWLVEN GCDGVVANGS LGEYQTLTDE
     ERAKVVETAV EAVGGRNVMA GVGAYGSAES RRWAERAGEA GCGSVLLLPP NAYRADERAV
     VAHYREVAGA GVPVVAYNNP YDTKVDLTPA LLARLHEEGL IVAIKEFSGD VRRAYELAEL
     APELDLLIGS DDVLLELAIA GAVGWIAGYP NALPASTVAL YRAAVARDLG TALPLYRTLH
     PLLRWDSKTE FVQAIKLSMD LAGRHGGPCR QPRQSLTDEQ AAIVRSATEK ALAEGLR
//