ID A0A5C6MJJ6_9TELE Unreviewed; 1034 AA.
AC A0A5C6MJJ6;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Prominin-1-A Prominin-like protein 1 {ECO:0000313|EMBL:TWW55364.1};
GN ORFNames=D4764_09G0004130 {ECO:0000313|EMBL:TWW55364.1};
OS Takifugu flavidus (sansaifugu).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433684 {ECO:0000313|EMBL:TWW55364.1, ECO:0000313|Proteomes:UP000324091};
RN [1] {ECO:0000313|EMBL:TWW55364.1, ECO:0000313|Proteomes:UP000324091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTHZ2018 {ECO:0000313|EMBL:TWW55364.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TWW55364.1};
RA Xiao S.;
RT "Chromosome genome assembly for Takifugu flavidus.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fibroblast growth factor-binding protein
CC family. {ECO:0000256|ARBA:ARBA00008326}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWW55364.1}.
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DR EMBL; RHFK02000022; TWW55364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C6MJJ6; -.
DR Proteomes; UP000324091; Chromosome 9.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR InterPro; IPR010510; FGF1-bd.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF06473; FGF-BP1; 2.
DR Pfam; PF05478; Prominin; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000324091};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1034
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023021576"
FT TRANSMEM 111..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 853..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 115713 MW; 7F5D5A40F05EB1DF CRC64;
MWTSAFVPLL LLLSVSAELR QDTEPRRLPP PGKLDFGYVP AGVYETVAHY EPGPIGILFQ
LVQGFLHIVQ PNAFPQDLIV KLAKDKFGAL QTEYQKPENI VLTLQAIYYE IGFLVCAAVG
LLFAILLPVV GLFFCMCRCC DNCGGEMHQR QRKNADCRRG LLGTLLFSTS LVITIGVLCA
YAANQNLSSQ VKNIRRYVNS NMRDLHTFAN DTPMQIDYLI SQYATAKNKV IYDLNTMRET
KEALENSSMG LEVLQDGTGK LGFNLSLVRT SINRTLSDPG CHDEKSDATT AQLCRNIRQS
LSQLQISANF TRLPNVNSQL ERMKDVLKMD LSIIVQKGFS SLNDTPHMVT EQTRSVVENV
QTLMDDIGKN ISSFSKIFPV QSCLSNFTIF ISHVHAKIED HYPEIDRMDF YRWIGCITLC
CMVVLVLAFN YLGLLCGTLG YDKHASPTTR GCISNTGGTM LIAGVGISFI FSWVLMGLVT
IIFLAGGNME KLVCEPFHTK EVVDTPYLVH PDWKNFIPGY LYNDSDMELT AESFYRQSKL
ILFFWHLSGV VFTCKDNRGI YSALRLDKVF NVSSFLNTTM FTKDVVARLN NVKIDLRGII
LLEAEGKQNL LDFSEAGLLE INYADYLEEV NKGVTVVDLL SFARELEAQT DLMPRGGLQM
ALKGHAGTLR QIHSQQIIPM EQAMSALNQS MRYLERTASD LPNKVLAVIE AIEAAQYLIS
HNATHLINQE TAKFTATIVG YFHQYIEWVK TALAMEVAPC KPFSNMIDTV EIVTCSFLVD
SMNTFWMGLG CSTLLLLPSI ILAVKLAKFY RRMETEDVYD DVCSADFMAV LTNISLLLAL
ACVSHQLVLS SSQKTHGKKG SRGQNKDKPV QNMGPQPKPA PARLKGKLVT TDKSECTWSV
TGNDLLTLRV TCQKGVSRFS CEYNARPSIC PQYSSKAELY WKQMARALKK QQSLCQESNV
PIKAGLCRRA AKDAHFRLSH VQEKTSTPPP PTQPEPRAVK SCQDDNMKRA EEYCSNSWSS
VCLFFFTMVQ DSDC
//
