ID A0A5C6N8M3_9TELE Unreviewed; 1191 AA.
AC A0A5C6N8M3;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Solute carrier family 12 member 6 {ECO:0000313|EMBL:TWW63513.1};
GN ORFNames=D4764_03G0005210 {ECO:0000313|EMBL:TWW63513.1};
OS Takifugu flavidus (sansaifugu).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=433684 {ECO:0000313|EMBL:TWW63513.1, ECO:0000313|Proteomes:UP000324091};
RN [1] {ECO:0000313|EMBL:TWW63513.1, ECO:0000313|Proteomes:UP000324091}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTHZ2018 {ECO:0000313|EMBL:TWW63513.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TWW63513.1};
RA Xiao S.;
RT "Chromosome genome assembly for Takifugu flavidus.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TWW63513.1}.
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DR EMBL; RHFK02000016; TWW63513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C6N8M3; -.
DR Proteomes; UP000324091; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000324091};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..331
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 478..756
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 770..887
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 902..1023
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1121..1191
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1057
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 130764 MW; EE173332358C679D CRC64;
MASVRFTVTP TKAEDLPGLS DTSPDISSRS GARVRFGSKE SVNRSEPLSE TSGGGATGIG
TPDHSSVDQG EGNSKISSVY INNTHGVDDD DFYDRNLALF EEEMDTRPKV SSLLSRLANY
TNLTQGAKEH EEAESIGEKK KTSKSPQMGT FMGVYLPCLQ NIFGVILFLR LTWVVGNAGV
LQGLCIVFIC CCCTLLTAIS MSAIATNGVV PAGGSYFMIS RSLGPEFGGA VGMCFYLGTT
FAGAMYILGA IEILLMYIAP KAAIFEAKHP EGEGAAMLNN MRVYGSICLL LMSLLVFVGV
KYVNKLASIF LACVIISIVS IYAGALVSAF KPPNFPVCML GNRTISGHEI DDNQCAKTIA
VRMEESTGGV DTNFTAIIDN STVAPTFDPS IPPLVNTTSI WKLFCNGPEL NASCDKYFNS
NNFSQIEGIP GLASGIISEN LWSSYLGKGE VLEKGSLESS DESPPASTHH PYVFADITTS
FTLLVGIFFP SVTGIMAGSN RSGDLKDAQR SIPIGTILAI LTTSFVYLSS VILFGACIDG
VVLRDKFGDS VQGNLVVGTL AWPTPWVIVI GSFFSTCGAG LQSLTGAPRL LQAIAKDNVI
PFLRVFGHGK ANGEPTWALL LTALIAELGI LIASLDMVAP ILTMFFLMCY LFVNLACALQ
TLLRTPNWRP RFSYYHWTLS FLGMTICLAL MFISSWYYAI VAMVIAGMIY KYIEYHGAEK
EWGDGIRGLS LSAARYALLR LEEGPPHTKN WRPQLLVLLK LDEDAHVKSP RLLTFASQLK
AGKGLTIVGT VVSGNFLQSY GEALAAEQTL KHLMDKERVK GFCQCIVAQK PREGINHMIQ
SSGLGGMKPN TVVMGWPHAW RQSEDPQSWK TFINTVRVTT TAHLALLVPK NISLFPNNSE
PYTEGYIDVW WIVHDGGMLM LLPFLLRQHK AGATISLFPF LFHVWRKCGM RIFTVAQMED
NSIQMKKDLA TFLYHLRIEA EVEVVEMHDS DISAYTYERT LMMEQRSQML RQMRLSKSDR
EKEGNPCSGS SRQEAVGAAR SQAQLVKDRN SMLRLTSIGS DDDEETDGER ERPSGGSTEH
HRRVQMTWTK EKTLQYRATH SGCSTPEGFR DMLSIRPDHS NVRRMHTAVK LNEVIVNKSH
DARLVLLNMP GPPRNTEGDE NYMEFLEVLT EGLERVLLVR GGGSEVITIY S
//
