ID A0A5C7H969_9ROSI Unreviewed; 1455 AA.
AC A0A5C7H969;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE RecName: Full=HhH-GPD domain-containing protein {ECO:0000259|SMART:SM00478};
GN ORFNames=EZV62_018939 {ECO:0000313|EMBL:TXG53683.1};
OS Acer yangbiense.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Sapindaceae; Hippocastanoideae; Acereae; Acer.
OX NCBI_TaxID=1000413 {ECO:0000313|EMBL:TXG53683.1, ECO:0000313|Proteomes:UP000323000};
RN [1] {ECO:0000313|Proteomes:UP000323000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Malutang {ECO:0000313|Proteomes:UP000323000};
RX PubMed=31307060; DOI=10.1093/gigascience/giz085;
RA Yang J., Wariss H.M., Tao L., Zhang R., Yun Q., Hollingsworth P., Dao Z.,
RA Luo G., Guo H., Ma Y., Sun W.;
RT "De novo genome assembly of the endangered Acer yangbiense, a plant species
RT with extremely small populations endemic to Yunnan Province, China.";
RL Gigascience 8:0-0(2019).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA glycosylase family. DEMETER subfamily.
CC {ECO:0000256|ARBA:ARBA00005646}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TXG53683.1}.
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DR EMBL; VAHF01000009; TXG53683.1; -; Genomic_DNA.
DR Proteomes; UP000323000; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0035514; F:DNA demethylase activity; IEA:InterPro.
DR GO; GO:0019104; F:DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR GO; GO:0080111; P:DNA demethylation; IEA:InterPro.
DR CDD; cd00056; ENDO3c; 1.
DR CDD; cd06222; RNase_H_like; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR044811; DME/ROS1.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003651; Endonuclease3_FeS-loop_motif.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR028924; Perm-CXXC.
DR InterPro; IPR044730; RNase_H-like_dom_plant.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR028925; RRM_DME.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 1.
DR PANTHER; PTHR46213:SF13; DEMETER-LIKE PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR46213; TRANSCRIPTIONAL ACTIVATOR DEMETER; 1.
DR Pfam; PF15629; Perm-CXXC; 1.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF15628; RRM_DME; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SMART; SM00525; FES; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR PROSITE; PS51375; PPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000323000};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 159..193
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 913..1055
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
FT REGION 29..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..518
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 165878 MW; 1EDB1BECBE08041E CRC64;
MVSKTSLVPS SSKTTFKARL LSSFTHSRNE VSSLSKHPNS KAKSMTEADP ARLRDSLHGK
CKSGKIDLDE AHYLFDYMIH MQPTPHMSSF NILFTVLVKN NHYGDVISLQ NIMNSVGRGF
NPNDVTFSRL IKGHTIVSLQ LHEQMVNGNS KYGGICKPGV VWYGIMIDGL CKDGFTDRAK
ELFFEMKANG IPANAVTFTT LIHDTAEVLV GVSYRIEISR ISVLHVVLWQ VNTDAAVDLN
DLRIGLGAVV RDNRGSVMAA CAQTSLVPVV VESDALQVVE FVSSQSPPSS EVGVVVLDIL
QLIDSVPVTG VMFVLRLANV VVHSLAFVVV WEQGLEKKKL QRKMSKLKVY RRRKTRGRTD
LEEKQLKREM SQLKVYQRRK TRSCIDLEEK QLQREMFPLK VYLRRKTRGR IDLKEKQFQR
EMTPLKVYQR QRWKTRGRID LEEKQLQREC SWVPGTPAKL GNSEEENTNI FTTESSCSQN
GQQTVQEDAV SEKQSENIQL KRKRQQKPKR KKHRPRVVVE GLKPKTPKPV TPKQTVPSKK
RKYVRKSSRQ GNSVSEERRL PKRRKSSKKT SKNNPDVEVA EKTSCRKTLN FNLESGQFQP
YVPSMFKKMR RRRLRRSDLA LLVAPPICNQ LPRLPAISRG VGRRSKMQGR NAQSSNSGDG
TLVPYQEHYI RNRKRITGKV YLDPDTMRVW NQLMNLKDRD ANEEQTDPEK EDQWRREREI
FQGRIESFTA RIHIILGDRR FKPWKGSVVD SVVGVYLTQN VSDCLSSSAY MSLAAKYPPK
TTSNNTSSTG AAYDFEGNLL YFVTEPEPDR SPELKNREEP LDEEKDLKNV VEPHTFEDSS
NVQLTPQRIN ESKAKHGFKS QDATIMRKIT SRGKGPKLKN DKAKKATPKE KKKDNKEKRD
WDLFRKMYSS DEQSSSDQMD SVDWEAVRLA EPREVAMAIK DRGQQNVIAG RIQKFLTRLV
EVHKSIDLEW LRHAPPDIVK EYLLEIPGLG LKSVECVRLL SLQHIAFPVD TNVGRIAVRL
GWVPLEPLPE SLQIHLLEQY PLMNTIQKYL WPRLCNLDQR TLYELHYQLI TFGKVFCTKR
NPNCGVCPLR GECKHFASAF ASARLALPRP SEKGIVYKRN PHVDVNPIPV TFLEAGMLPR
PSEKGNPHVD VNPIPVTLLE ADLLSEAGIL NNCEPTIEEP ASPETQCTEM SSEPDLEDFC
CGEPEEIPTI RLQDREFNIE QIQIFLETNK MMLQKSRDLV LLAAEATSMP APKLKSVNRL
RTEHLVYVLP DNHLLLQGFG RRDTDDTCPY LLSIWTPGET PNSFEKPTKK CNSGESELCN
EKTCYSCSTI QEQNADIVHG TILIPCRTAN IGRFPLNGTY FQVNEVFADH ETSHQPICVP
RSMIAQLLTQ TAYFGTSATS IFRGLDLVEI QRCFWTGYIC VRGFERKNGA PRPLSRRLHT
PPSKMGKAYD KWNDE
//
