ID A0A5C8JF31_9BACT Unreviewed; 988 AA.
AC A0A5C8JF31;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:TXK36910.1};
GN ORFNames=FVR03_16525 {ECO:0000313|EMBL:TXK36910.1};
OS Pontibacter qinzhouensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC Pontibacter.
OX NCBI_TaxID=2603253 {ECO:0000313|EMBL:TXK36910.1, ECO:0000313|Proteomes:UP000321926};
RN [1] {ECO:0000313|EMBL:TXK36910.1, ECO:0000313|Proteomes:UP000321926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GY10130 {ECO:0000313|EMBL:TXK36910.1,
RC ECO:0000313|Proteomes:UP000321926};
RA Shi S.;
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TXK36910.1}.
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DR EMBL; VRTY01000068; TXK36910.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5C8JF31; -.
DR OrthoDB; 9811314at2; -.
DR Proteomes; UP000321926; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF17; PROTEIN YHJJ; 1.
DR Pfam; PF00675; Peptidase_M16; 2.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000321926};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 75..114
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 273..440
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 605..695
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 767..894
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 988 AA; 111521 MW; 70E53BAD21D6CD45 CRC64;
MKKGMSLFLI ALAFTFTQCK NEAYQAQSTT AATATATAEP AQKEYKYETV PNDPLNARIY
TLENGLKVYL TDYEDAPRIQ TYIAVRAGSK NDPANATGLA HYLEHMVFKG TTQLGTQNWE
KEKAELDKIE ALYEQHRNTT DAAVRKKIYH QIDSISGVAA TFAVANEYDK ILGAIGAKGT
NAYTSVEQTV YTNDIPANQL ERWVALEADR FGELVPRLFH TELEAVYEEK NRSLDNDGWK
MYEALNSGLF PTHQYGTQTT IGTIEHLKNP SITEIKKYFD QYYVPNNMAV ALSGDIDFDE
TIRIIDAHFG KLKNKPVPAF TVAQEKPIAQ PVVKEVVGPS AESIAIGYRF PGMSSRDALV
LSMISNILYN GQAGLIDLNL NQQQKVLQAY GYDNQMKDYS VFRLGGSPRQ GQSLDEVKKL
LLAQVEIVKQ GKFEDWLIPA VVNDYKITLM QEYENNNNRA DAFVTAFVND MDWKTYVNRP
EEFAKITKQD VMEVASKYLN DNYVLVYKRT DKNAEVAKVE KPTITPVPVN RDAQSAYYKA
FMAADAPALS PVFVDYKTDI KEEKLKNDIP LLYTQNKENG LFQLYYILDM GTNNDPKLGM
AVNYLRYLGN DKFSAEELKK EFFKLGTSFN VSTSGDQVYV TLSGLDENFE EALALFENTL
QNPKPDQEAL KDMVDGVLKS RADAKLNKSV ILNQALVNFA KYGPKNPFTT NLTEKQLKAV
KPQELVSIIK SIPTYEHRVL YYGPRETPAI VAALNTGHQV PAKLKAVPAE KVYAELEIKK
PAVYWVDYNM VQAELLFLTK SLPYDKTMVP TARLYNEYFG GGMSSIVFQE LRESKALAYS
AYSAYSTATK KDRSNYNLSY IGTQADKLPE AMVGMQELLN NMPLADENFA NAKASLRNSI
SSERITKSSI LFDYERAKRL GLDYDIRRDV YESANSLTFS QLQEFQQKYI KGQPQAILVI
GSKDRLNFKE LAKYGQVKQL QLEEIFGY
//
