GenomeNet

Database: UniProt
Entry: A0A5D3DFQ4_CUCME
LinkDB: A0A5D3DFQ4_CUCME
Original site: A0A5D3DFQ4_CUCME 
ID   A0A5D3DFQ4_CUCME        Unreviewed;       276 AA.
AC   A0A5D3DFQ4;
DT   13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Pyrroline-5-carboxylate reductase {ECO:0000256|RuleBase:RU003903};
DE            EC=1.5.1.2 {ECO:0000256|RuleBase:RU003903};
GN   ORFNames=E5676_scaffold523G00130 {ECO:0000313|EMBL:TYK22531.1},
GN   E6C27_scaffold382G00640 {ECO:0000313|EMBL:KAA0062733.1};
OS   Cucumis melo var. makuwa.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX   NCBI_TaxID=1194695 {ECO:0000313|EMBL:TYK22531.1, ECO:0000313|Proteomes:UP000321947};
RN   [1] {ECO:0000313|EMBL:TYK22531.1, ECO:0000313|Proteomes:UP000321947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Chang Bougi {ECO:0000313|Proteomes:UP000321947};
RC   TISSUE=Leaf {ECO:0000313|EMBL:TYK22531.1};
RA   Kwon S.-Y.;
RT   "Draft genome sequences of two oriental melons (Cucumis melo L. var
RT   makuwa).";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC         NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003903};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline
CC       from L-glutamate 5-semialdehyde: step 1/1.
CC       {ECO:0000256|RuleBase:RU003903}.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC       {ECO:0000256|ARBA:ARBA00005525, ECO:0000256|RuleBase:RU003903}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TYK22531.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; SSTE01004182; KAA0062733.1; -; Genomic_DNA.
DR   EMBL; SSTD01004966; TYK22531.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5D3DFQ4; -.
DR   STRING; 1194695.A0A5D3DFQ4; -.
DR   UniPathway; UPA00098; UER00361.
DR   Proteomes; UP000321393; Unassembled WGS sequence.
DR   Proteomes; UP000321947; Unassembled WGS sequence.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 1.10.3730.10; ProC C-terminal domain-like; 1.
DR   HAMAP; MF_01925; P5C_reductase; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   InterPro; IPR029036; P5CR_dimer.
DR   InterPro; IPR000304; Pyrroline-COOH_reductase.
DR   NCBIfam; TIGR00112; proC; 1.
DR   PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR   PANTHER; PTHR11645:SF0; PYRROLINE-5-CARBOXYLATE REDUCTASE 3; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   Pfam; PF14748; P5CR_dimer; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU003903};
KW   NADP {ECO:0000256|ARBA:ARBA00022857, ECO:0000256|PIRSR:PIRSR000193-1};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003903};
KW   Proline biosynthesis {ECO:0000256|RuleBase:RU003903};
KW   Reference proteome {ECO:0000313|Proteomes:UP000321393}.
FT   DOMAIN          12..107
FT                   /note="Pyrroline-5-carboxylate reductase catalytic N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03807"
FT   DOMAIN          169..273
FT                   /note="Pyrroline-5-carboxylate reductase dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF14748"
FT   BINDING         16..21
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
FT   BINDING         65
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000193-1"
SQ   SEQUENCE   276 AA;  28789 MW;  6A0FAA75D5647042 CRC64;
     MEVLPISIDA YRLGFIGAGK MAESIAKGIV QSGLLPPSRI STAVHSNPSR RIAFESFGVR
     VLPKNDNVVE ESDVVILSVK PQVVKNVVLK LRPLLSGKKL LVSVAAGVKL KDLQDWAGHN
     RFVRVMPNTP AAVGEAASVM SLGEGAIKED GQLVAKLFGS VGKIWEAEEK YFDAITGLSG
     SGPAYIFLAI EALADGGVAA GLPRELAMGL ASQTVLGAAS MVTKTGKHPG QLKDDVTSPG
     GTTIAGIHEL EKGGLRGMFM NAVVAAAKRG QELSPK
//
DBGET integrated database retrieval system