ID A0A5E4AG02_MARMO Unreviewed; 186 AA.
AC A0A5E4AG02;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Thymidine kinase 2 mitochondrial {ECO:0000313|EMBL:KAF7482569.1};
GN ORFNames=GHT09_006124 {ECO:0000313|EMBL:KAF7482569.1}, MONAX_5E029969
GN {ECO:0000313|EMBL:VTJ56353.1};
OS Marmota monax (Woodchuck).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Marmota.
OX NCBI_TaxID=9995 {ECO:0000313|EMBL:VTJ56353.1, ECO:0000313|Proteomes:UP000335636};
RN [1] {ECO:0000313|EMBL:VTJ56353.1, ECO:0000313|Proteomes:UP000335636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF7482569.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WC2-LM {ECO:0000313|EMBL:KAF7482569.1};
RC TISSUE=Liver {ECO:0000313|EMBL:KAF7482569.1};
RA Shumante A., Zimin A.V., Puiu D., Salzberg S.L.;
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
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DR EMBL; WJEC01000546; KAF7482569.1; -; Genomic_DNA.
DR EMBL; CABDUW010000064; VTJ56353.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5E4AG02; -.
DR Proteomes; UP000335636; Unassembled WGS sequence.
DR Proteomes; UP000662637; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KAF7482569.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000335636};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..179
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 54
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 113..117
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 186 AA; 22097 MW; 51A9027CD8F238F9 CRC64;
MEPVSKWRNV RGHNPLGLMY QDACRWGLTL QTYVQLTMLD RHTCPQMMPV RLMERSLHSA
RYIFVENLYR SGKMPEVDYV ILSEWFDWIV RNIDVSVDLI VYLRTTPETC YERLKKRCRQ
EEKVIPLEYL GALHQLYEEW LITGSLFPAA APVLVIEADH NMEKMLELFE QNRARILTPE
TWKHGP
//
