ID A0A5E4CV97_MARMO Unreviewed; 1400 AA.
AC A0A5E4CV97;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=MONAX_5E011034 {ECO:0000313|EMBL:VTJ85089.1};
OS Marmota monax (Woodchuck).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Marmota.
OX NCBI_TaxID=9995 {ECO:0000313|EMBL:VTJ85089.1, ECO:0000313|Proteomes:UP000335636};
RN [1] {ECO:0000313|EMBL:VTJ85089.1, ECO:0000313|Proteomes:UP000335636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}.
CC -!- SIMILARITY: Belongs to the S100-fused protein family.
CC {ECO:0000256|ARBA:ARBA00038258}.
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DR EMBL; CABDUW010002020; VTJ85089.1; -; Genomic_DNA.
DR Proteomes; UP000335636; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR22571:SF24; FILAGGRIN-2; 1.
DR PANTHER; PTHR22571; FILAGGRIN-RELATED; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000335636}.
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 99..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..1294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1330..1376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 145155 MW; BA7C3BA15413D315 CRC64;
MTDLLRSVVT VIDIFYKYTK QDGECGTLSK DELKELLEKE FRPILKNPDD PDTVDVIMHM
LDRDHDRRLD FTEFLLMVFK LAMACNKVLS KEYCKASGSK KHRHGHRYQE EENETEEEEE
ETPRRKKGYR HSSWNEGEEH GYSSGGSRGT AKYRHGSNSR RLRRQGELSS SEGSEKRYQG
SGSGHSWSSG KERHGSNSGE LRERNKSYGS PSRESGEEYV SGSKSQGRKS HGGFSHGLET
SEHESNSTQS RKSGGQNLGS SSEGSGDSRR QSHECGYSNS GGCGRPQNAS SSYQTSRFKG
PGNQSSCPQS GCQSGSSGGQ GHRCVSGGQS SGYGQSDPSS CRQSCSQRRC ESKQCGQPQN
CGGQQGTGSS QSSCCAKYGC GTSQSSSCGQ HRSGSCRQSS NSHQKGSGPN EFSKCGHHGS
GSGQSCSCEQ HGPGSGQSSG LGHHGSGIGQ SCCGQYGSGS SQSSGCGQHG SGSSQSSGCG
QHGSGSSQSS GCGQHGSGSS QSSGFGQHGS GTGQSSGFGQ HGSGSGQSSG FGQHGSGSGH
SSGFGQHTSG SGHSSGLGQH GSYTGQSSGF GQHGSGSGQS SGFGQHGSGT GHSSGFGQHG
SGSGQSSGFG QHTSGSGQSS GFGQHGSGSG QSSGFGQHTS GSGQFSGFGQ HGSGSGQSSG
FGQHTSGSSQ SSGFGQHTSS SGQSSGFGQH GSGTGQSSGL GQHESGSGHS SGFGQHTSGS
GQSSGFGQHG SGTGHSSGFG QHGSGSGQYS GFGQHTSSSG QSSGFGQHGS GSGQSSGFGQ
HGYGSGQSSG FGQHTSGSGQ SSGFGQHTSG SGQSSGLGQH GSGSGQSSGF GQHGSGTGQS
SGFGQHGSRS GQSSGFGQHG SGTGQSSGFG QHGSGMRQSS GFGQQESGSG QSSGLGQHGS
GSGHSSCCGK HTSGMGQSSA GSTDSERQET SHGQSRDTTR RSQSGQRQST RSGSRPTPQR
TPIHTESSES EEHSGISHRH SGSSQGHAGS QHGEAGSTHS ERHQTGHEQS QGSTRHAHSG
LGQSPESSSH ITPRRSPVHN ESTDSEHKSA ISQRHSASAH SHAGSQHGEL GSGHTQPHNI
HQQSRDSVRS QSSSIYGQSG RRHFESQNNR KQRHGSGHHW RHGSYGRSEY DYGQSGYGPS
GHSRSSSRTS SPLRSTDRPI STSVSTHGQS FSISDQTEFK ATGREGRQVS KHGQFEASQG
QLVDSQEQSG SRITRQGSNH AHSVITSEQS SNTNVQSQFG TIGNQGSIHS PSYDQSGSND
RQYMSFSSTR KQSGFTNERQ KYSQSQPSNT YEQSIDNITG SQRSFSNYSL YSQDPMGSEE
YRYLSRNSTI LGGGSQEQES GSNPSGGISR YSQDVDDTQT RGSEARDYHR KARMDSGSLY
IDSSTPLYEY VQEQRCYYFE
//
