ID A0A5E4M9R1_9HEMI Unreviewed; 338 AA.
AC A0A5E4M9R1;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 10.
DE SubName: Full=Peptidase C1A, papain C-terminal,Cysteine peptidase, asparagine active site,Cysteine peptidase {ECO:0000313|EMBL:VVC28252.1};
GN ORFNames=CINCED_3A006381 {ECO:0000313|EMBL:VVC28252.1};
OS Cinara cedri.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Lachninae; Cinara.
OX NCBI_TaxID=506608 {ECO:0000313|EMBL:VVC28252.1, ECO:0000313|Proteomes:UP000325440};
RN [1] {ECO:0000313|EMBL:VVC28252.1, ECO:0000313|Proteomes:UP000325440}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Alioto T., Alioto T., Gomez Garrido J.;
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABPRJ010000479; VVC28252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5E4M9R1; -.
DR Proteomes; UP000325440; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF971; CATHEPSIN L-RELATED; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000325440};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5022801892"
FT DOMAIN 29..89
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 119..337
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 338 AA; 37771 MW; 0BEF658B039F5C93 CRC64;
MKVFVILGLV AISISAVCSI TINDISEEWN LFKVKYNKTY KNIEDELFRK KLYLKNKIVI
EEHNKLYKKG QVTYKLKMNQ FGDMANHERK YMNGFNQILK NNIDDRDSVT YLSPENVNIP
SSIDWRKLGA VTPVKDQGHK CGSCWAFSST GSLEGQQFRK TGKLVSLSEQ NLIDCSRMYG
NHGCRGGLMD QSFKYIKLNG GIDTENSYPY KGKNGYFCKY NPQNKGATVT GTVDIATGDE
DALAEAVATV GPISVGVDAS SDNFSFYSEG VFYEPTCSST IIDHAILAVG YNTTEAGEDY
WIVKNSWGEE WGQGGYIWMA RNKNNNCGIA SMASYPLV
//
