ID A0A5F5PL72_HORSE Unreviewed; 1843 AA.
AC A0A5F5PL72;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Polycystin 1 like 1, transient receptor potential channel interacting {ECO:0000313|Ensembl:ENSECAP00000049042.2};
GN Name=PKD1L1 {ECO:0000313|VGNC:VGNC:21488};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000049042.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000049042.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000049042.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000049042.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000049042.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9796.ENSECAP00000049042; -.
DR PaxDb; 9796-ENSECAP00000049042; -.
DR Ensembl; ENSECAT00000072950.2; ENSECAP00000049042.2; ENSECAG00000043691.2.
DR VGNC; VGNC:21488; PKD1L1.
DR GeneTree; ENSGT00940000162104; -.
DR InParanoid; A0A5F5PL72; -.
DR OMA; MAVTAYH; -.
DR Proteomes; UP000002281; Chromosome 4.
DR Bgee; ENSECAG00000043691; Expressed in articular cartilage of joint and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR46730:SF4; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 731..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1118..1141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1266..1285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1521..1541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1561..1582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1609..1627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1648..1665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1671..1691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1712..1734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..551
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 776..895
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1843 AA; 205172 MW; D4F48481C0C62F2D CRC64;
MYRGSTAGGP AAPRGTPQHE GSPRPSPSGR SSPPQSPAPH LPDFEAYYSD IQEAMPSKGR
QPGDWTNINL PGSGPNVNAD ESHGDGDNLL GPFLPTVSAR PVLMVDWPKS LVRRAVFHGY
TSSGITEQTV TIKPYSLSPG ETYVLQASVA SKDSFLGKAQ LYLTTNQAPR DVACQVQPHR
GLEAHTIFSV FCMSGRRDFR YEFSYQIGNN AKRTLYHGRD SQYYFALPAG EPLDDYKVMV
STEITDGEGS QVQPCTVAVT VLPRFQGNHC PGEDVYNSSL KTLSTLQLMG SYTEIRNYVT
MITRVLSRWA KEDRSPSCGQ WSRIQDALIS SVCRLAFADQ EEMNDSVLML RDLIHFPNKL
SFTSAVLIIK YARVLRARSP LLGRFVVDKE QMLELILLVS GVLEASDREK SRNADYPQDE
GIKVISDLLL DRLSSNSERQ LHISTGQMEI LTLLHHEPQS SVQSLGPIQV HLPGDLAGQS
PAGPGMQSPC YVSQLMLFKK NPYPGGRAGE MGRVLHLSLY NCSSRRPFSR HRLRKPVTLE
FGEEGGPDNR RNSSTFVLLR DKVNFHQFAG PSEDPQESLQ IRIEFSKPVT RAFPVMLLVR
FSEKPTPSDF LVKQIYFWDE QIVHIYVPAV SLKDTNLGYL SLLDADYDRK PLNKYLAKSV
NYAVHFQWIR CLFWDTGEWK SESFSPQPGT SPEKVNCSYD RLAAFSVTRR RLNASFETSD
ISKLQGHPEN LLPAIFIVVF TILYALLVTK SRRVDRHEKK KTGYIFLQEN APPDQQLYAV
VVDTGFRAPA HFTAKVYIVL CGENGLSEPK ELYCPEKPLF ERNSRHTFIL SAPAPLGPLQ
KIRLWHDSRG HSPAWYVSHV MVKELCAGQG QSWLFPAECW LAVSRWDGRV ERELACLCRG
PGFWKLWYWK FMEYLEDFHV WTSVLSRPSG SGLLHTPRLT VAFAVLCAYA GLTALLTTVG
QEQLMLDVGP TEVTLGSFWM GFLCTLLASP GAQLLSLFFR LSQEARGPPG EEPHLPLRAV
RTEAAQGPNS SRRMPDAQKT YKHNVLSENG GAPRRAASSD GAGCSPPEPE ADRADLSQPA
PREESDPCTL SLQGPGGGFE ELTVPRWPRA PLPWSGSAAW VLCGMVSVAC GLGTGFLGYR
FSPTQCLQWL RLLALSVVCC VFVTQPLMIG LAALGFAWRR KDDKHFFTES LREATKGLDS
ELEELSRTRM PLSSGCSIPD SASEVEKVLA ARQRARRLRW ACPPSPAQLR VTRERMRREM
RTREELRDIC MYILMLLLHL FIIHGKFSGD EYSLNRAIQN EFTRVPEIYT RGKELFVSGL
ALRSARSSSS SLRSVDEWWD WSLTTLLDGL YQESSFTAGT LGAQPGALGG KFYLTGPSVI
KQMKVPPGSL CELPSPPSAH IEGSLPTHNP TVGSPESPSV IDPEIQRVAL SGPGGCREDC
VLSLGRTRPA ARAALTRLRA SRWINCSTRA VSVHFTLYNP PTQLFSSVSL NANMLPTGGL
ALSSLVESFH IFRSNSARYR LMLPELLFLV LNLIHLCFQL YGMMEKGVRN YWRKPRNWLE
LSIVGAALTY SAASGHLGTL AGEVTDQFHR GLFQEFTDLS HMAAWNQRAR WLQGILSFLL
ILKCIYLPGI RNTMASCSFT ARRSLSSIFA PGLAGVLMLA AHTHLRGFLL SAWALPSGAF
SDSFHGLLFH FPGRSQRDTF LGLSKSDRRD MACCYGAFLI AVTTLWFGML RGFLMTLGRK
RKSFQSKSLV RLKDMTAYMV GKTLTLLGLE RPKLDETEMV ENHNYYLDEF ADLLDELLLK
ITGLSDSLQP PFLEQQSSDT VEAGSEDSPL AGVSAYQLTG VGG
//
