ID A0A5F5XPT8_FELCA Unreviewed; 518 AA.
AC A0A5F5XPT8;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Rho GTPase activating protein 8 {ECO:0000313|Ensembl:ENSFCAP00000056114.1};
GN Name=ARHGAP8 {ECO:0000313|Ensembl:ENSFCAP00000056114.1,
GN ECO:0000313|VGNC:VGNC:109246};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000056114.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000056114.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056114.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000056114.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056114.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000056114.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000056114.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F5XPT8; -.
DR Ensembl; ENSFCAT00000081416.1; ENSFCAP00000056114.1; ENSFCAG00000014797.6.
DR VGNC; VGNC:109246; ARHGAP8.
DR GeneTree; ENSGT00940000160758; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000014797; Expressed in adult mammalian kidney and 11 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF4; RHO GTPASE-ACTIVATING PROTEIN 8; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 77..232
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 259..450
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 59413 MW; 6989F076F9D314AC CRC64;
MAMVSEGPRA RTPERWHRSR VLGHPGEQQN MSQPDLEELA EIELQRDEEK AAALSIVRKP
LVVPTTDQDP ALSVNHPFYD VARHGILQVA GEDRFGRRVI TFSCCRMPPS HELNHRRLLE
YLKHTLDQYV ESDYTIVYFH YGLNSRNKPS LGWLQSTYKE FDRRYKKNLK ALYVVHPTNF
IKVLWTIFKP LISHKFGRKV IYFNYLSELR EHLKYGQLIV PPEVLRYDEK LRNLHGGQVP
APAKTPPPRP PLPTQQFGVS LQYLKDKNQG ELIPPVLRFT VTYLREKGLR TEGLFRRSAS
VHTIREIQRL YDQGKPVNFD DYGDVHIPAV ILKTFLRELP QPLLTFTAYE QILGITSVES
SLRVTRCHQI LQSLPEHNYA VLRYLMGFLH EVRGLSRARG GEAPIPCLAQ AALPAPGAHT
ARGPGSPPAL ERRSLAQKTS RPDRGAAPFL RLALLTGHMP GRPRLQMGPS FYFYSLTSAY
FERQHRWGGA ERRRENPKQT PRRPDAGQPQ SRVRGSTD
//
