ID A0A5F7Z8K1_MACMU Unreviewed; 1387 AA.
AC A0A5F7Z8K1;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Erythrocyte membrane protein band 4.1 like 3 {ECO:0000313|Ensembl:ENSMMUP00000061462.1};
GN Name=EPB41L3 {ECO:0000313|Ensembl:ENSMMUP00000061462.1,
GN ECO:0000313|VGNC:VGNC:72233};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000061462.1, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000061462.1}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000061462.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; A0A5F7Z8K1; -.
DR Ensembl; ENSMMUT00000082256.1; ENSMMUP00000061462.1; ENSMMUG00000019418.4.
DR VEuPathDB; HostDB:ENSMMUG00000019418; -.
DR VGNC; VGNC:72233; EPB41L3.
DR GeneTree; ENSGT00940000157047; -.
DR Proteomes; UP000006718; Chromosome 18.
DR Bgee; ENSMMUG00000019418; Expressed in primary visual cortex and 21 other cell types or tissues.
DR ExpressionAtlas; A0A5F7Z8K1; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17203; FERM_F1_EPB41L3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR030691; Band4.1-L3_FERM_F1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF20; BAND 4.1-LIKE PROTEIN 3; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 255..536
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 104..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..1015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 153650 MW; 9A520633821349A8 CRC64;
MSGRGEGAGE ARPSSKWKSR AKAIGIGSCL QASSAEPDPA PGRRRLCPCN CPEVLRWPPP
PRLGGQAGRG WLSLRGLWAW APAAAPRSLG VSCNRGRGEP RRAALGCGFL PTPESPAHRR
RGRAPEPGLH AAARLGYPLI PEQSTMTTES GSDSESKPDQ EAEPQEAAGA QGRAGAPVPE
PPSEEQQQAL EQFASAAAHS TPVRREVTDK EQEFAARAAK QLEYQQLEDD KLSQKSSSSK
LSRSPLKIAK KPKSMQCKVI LLDGSEYTCD VEKRSRGQVL FDKVCEHLNL LEKDYFGLTY
RDAENQKNWL DPAKEIKKQV RSGAWHFSFN VKFYPPDPAQ LSEDITRYYL CLQLRDDIVS
GRLPCSFVTL ALLGSYTVQS ELGDYDPDEC GSDYISEFRF APNHTKELED KVIELHKSHR
GMTPAEAEMH FLENAKKLSM YGVDLHHAKD SEGVEIMLGV CASGLLIYRD RLRINRFAWP
KVLKISYKRN NFYIKIRPGE FEQFESTIGF KLPNHRAAKR LWKVCVEHHT FFRLLLPEAP
PKKFLTLGSK FRYSGRTQAQ TRRASALIDR PAPYFERSSS KRYTMSRSLD GASVNENHEI
YMKDSVSAAE VGTGQYATTK GISQTNLITT VTPEKKAEEE RDEEEERRRK GEEVTPVSAI
RHEGKTDSER TDTAADGETT ATESDQEEDA ELKAQNSLIK RIKGENVYVK HSNLMLEELE
KTQDDLMKHQ TNISELKRTF LETSTDTAIT NEWEKRLSTS PVRLAARQED APMIEPLVPE
ETQEETEISE TVIFLQQGST PFLESQPSVI KKMQEGDSAD SVVTSRQIIF QKTVPSTLEG
TEDWVIVDKI PTEVVDGDSK KIVTYKVVTV SSRTGDLPAD ILKSGTIKMH SFEDLAREMQ
LKEDSKQKIY TLGKSYDTVS GRIVTMTGKA KEGEQVGQPS TMEALQKMEK EMSESVKIIP
GLEYEVLEAL ADEKSKRGPE VQTTKRKLSE SLAPIKEAES RRQSPEEDDL EKPPQQGKDV
AVLPGLEGRR FSKTEQVPES EVLKVGLFGP RRKSLSEWRY SQEPAFTVAT AHYVTESSAS
RVVTKQSSGE KLMDGSEIFS LLESARKPTE FIGGVTSTSQ SWVQKMETKT ESSGIETEPT
VHRLPLSTEK VVQETVLVEE RHVVHASGDA SYSVGDSGDA AAQPAFTGIK GKEGSALTEG
AKEEGGEEVA KAVLEQEETA AASREQQEEQ SAAIHVSETL EQKPHFESST VKTETISFGS
VSPGGVKLEI STKEVPVVHT ETKTITYESS QVDPGTDLEP GVLMSAQTIT SETTSTTTTT
HITKTVKGGI SETRIEKRIV ITGDADIDHD QALAQAIKEA KEQHPDMSVT KVVVHKETEI
TPEDGED
//
