ID A0A5F8H0I7_MONDO Unreviewed; 1074 AA.
AC A0A5F8H0I7;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 3 {ECO:0000313|Ensembl:ENSMODP00000053378.1};
GN Name=SORCS3 {ECO:0000313|Ensembl:ENSMODP00000053378.1};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000053378.1, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000053378.1, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000053378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A5F8H0I7; -.
DR Ensembl; ENSMODT00000076090.1; ENSMODP00000053378.1; ENSMODG00000010798.4.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000010798; Expressed in spinal cord and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 997..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 731..775
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 23..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 120678 MW; 97764BA7F2729978 CRC64;
EYDNSLPESF SISLRGSAPA ALGKLGARRS RRAQPPGSLA HWGSRGNSLA DGSRGSRAPA
KGSLEEGRGP RARGAAAEEL KLTSTSFALT GDSAHNQAMV HWSGYNSSVI LILTKLYDFN
LGSVTESSLW RSTDYGTTYE KLNDKVGLKT VPEYLYVNPT NKRKIMLLSD PEIESSILIS
SDEGATYQKY RLNFYIQSLL FHPQQEDWIL AYSLDQKLYS SMDFGRRWQL ILFDIHSLTL
MFIDPLFYAK DYSYAHYLTC RIQECSETTK SGPFARSIDI SSLVVQDEYV FIQVTSSGRA
SYYVSYRREP FAQIKLPKYS LPKDMHIIST DENQVFAAVQ EWNQNDTYNL YISDTRGVYF
TLALENVKSS RGLEGNIIID LYEVAGIKGI FLANKKVDDQ VKTYITYNKG RDWRLLQAPD
TDLRGNPVNC LLPFCSLHLH LQISENPYSS GRISSKDTAP GLVVATGEDD AISWIFDEEY
NIWFLDWGGA LVAMKHTSMP IRHLWVSFDE GSSWDKYGFT SAPLFVDGSL VDPGVESQIM
TVFGHFSLRS EWQLVKVDYK SIFSRRCNKD DFQTWHLLNQ GEPCVMGERK IFKKRKPGAQ
CALGRDYSGT VVSEPCICAD WDFECDYGYD RHGDNQCIPA FWYNPSSPSK DCSLGQSYLN
STGYRRIVSN NCTDGLREKY TAKSQQCPGK APRGLHVVTV DGRLVAEQGH NATFIILMEE
GDLQRTNIQL DFGDGIAVSY ANFSPVEDGI RHVYKSAGIF QVTAYAENHL GSDTAVLFLH
VVCPVEHVHL SVPFVAIRNK EVNVTAVVWP SQLGTLTYFW WFGNSTKPLI TLNSSISFMF
TSEGLNTITV QVAAGNALIQ DSKDIAVHEY FQSQLLSFSP NLDYHNPDIP EWRQDIGKVI
KRALVKVTSV PEDQILVAVF PGLPTSAELF ILPHKNMTER RKGNEADLEQ IAELLFNALN
QNLVQFELKP GVQVIVYVTQ LTLAPLVDSS TGHSSSAMLM LLSVVFVGLA VFLIYKFKRK
IPWINIYAQV QHDKEQEMIG SVSQSENAPK ITLSDFTEPE ELLDKELDTR VIGK
//
