ID A0A5F9CEJ9_RABIT Unreviewed; 3851 AA.
AC A0A5F9CEJ9;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=A-kinase anchoring protein 9 {ECO:0000313|Ensembl:ENSOCUP00000031994.1};
GN Name=AKAP9 {ECO:0000313|Ensembl:ENSOCUP00000031994.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000031994.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000031994.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000031994.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000031994.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000031994.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; AAGW02035355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02035362; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9986-ENSOCUP00000003916; -.
DR Ensembl; ENSOCUT00000044368.1; ENSOCUP00000031994.1; ENSOCUG00000004524.4.
DR GeneTree; ENSGT00730000110871; -.
DR Proteomes; UP000001811; Chromosome 10.
DR Bgee; ENSOCUG00000004524; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR028745; AKAP9/Pericentrin.
DR InterPro; IPR019528; PACT_domain.
DR PANTHER; PTHR44981:SF1; A-KINASE ANCHOR PROTEIN 9; 1.
DR PANTHER; PTHR44981; PERICENTRIN-LIKE PROTEIN, ISOFORM F; 1.
DR Pfam; PF10495; PACT_coil_coil; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 3648..3729
FT /note="Pericentrin/AKAP-450 centrosomal targeting"
FT /evidence="ECO:0000259|Pfam:PF10495"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1681..1705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2597..2621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3320..3348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 156..240
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 269..465
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 494..634
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 713..789
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 814..880
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 944..999
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1143..1170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1234..1268
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1324..1358
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1571..1641
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1884..1984
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2014..2202
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2234..2355
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2634..2696
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3063..3227
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3536..3563
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2597..2615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3851 AA; 444142 MW; 302236D1A2E8E490 CRC64;
MEDEERQKKL EAGKAKLAQF RQRKAQSDGQ NPTKKQKKKR KTLSSKQDVS AYDGLNVDQP
QREEKRMNSC QGVGPTGTPE STESRTLHSG EIIKAKQVSA EPESEISTTA DDYSSEVNGC
SFVVRTGMPT DLLREEEFGV DDSYSEQGAQ YSQTHLEMME SELTGKQQEI EELSRELEEL
RATYGTEGLQ QLQEFEAAIK QRDGIITQLT ANLQQARREK DETMREFLEL TEQSQKLQIQ
FQHLQASETL RNSTHSSTAA DLLQAKQQIL THQQQLEEQD HLLEDYQKKK EDFKMQISFL
QEKIKVYEME QDKKVENSNK EEIQEKEAII EELNTKIIEE EKKTLELMDK VTVSDKLLGE
LQEQIVQKNQ EIKNMKIELT SSKQKERQCS EEIKQLMGTV EELQKRNHKD NQFEVDIVQR
MEQETQRKLE QLRAELDEMY GQQIVHMKQE LIKQHMSQIE ELKTRHKGEV ESALKSYPHT
TVNEDQVKLM NMAINELNIK LQDTNSQKEK LKEELGVISG EKSALQRQLE DLFEELSFSR
DQIQRARQTI AEQESKLNEA YRSLGTVEDL KAQIVCASES RKELELKHEA EVTNYRIKLE
MLEREKNAVL DRMAESQEAE LERLRTQLLF SHEEELCKLK EDLEIEHRIN TEKLKENLGI
HYKQQIDGLQ NEMSQKIETM QFEKDNLITK QNQLILEISK LKDVQQSLVN SKSEEMTLQI
SELQKEIEIL RQEEKEKGTL EQEVQELQLK TELLEKQMKE KEDDLQEKCA HLEAENSILK
DEKKTLEDML KTHTSVNEEE GVIVVDPVES KSKDSSWQNE IEILTKQNED LKQKCIQLNE
EIERQRNTFS FAEKNFEVNY QELQEEYACL LKVKDDLEDS KNKQELEYKS KLKALNEELH
LQRINLPTVK MKTSVSDEEK TLVTEPLELG EVVEKDTTEL MEKLEITKRE KLELSERLSD
LSEQLKQKHV EISFLSEEVK SLKQEKEQFL LRCRELEIII NHSRTENTHV DDVPLSSLKD
GAVTVTSRDS GSSVSQINQC SGEESKLMVE DKIPFANLTI RKESEPEQLF LDHLPLVTNE
SSFGASESSE SDKLQQELRV LKSEQNDLRL QMEAQRICLS LVYSTHVDQV REYMENEKDK
ALCRLKEELI SAQEEKIKEL EKIHQLELQN TKTKEAGDEA KPLQVLIGKL QKAVSEECSC
ISQTLCSVLG EYYTPTLKCE INLEERENST VFTSENQESE LQDYRYKVQD FQENMQTLLN
KITEEYNKLL LLQTRISKGQ PVDGMKLEFA EESLSKEETK LLSVHSQRPN LHDIDINHKS
KLPSREDTEK MKQLEEQVKE LEHLVSSLQQ QLKETAGSSG TEVPCLQERL HPVHESPLQT
SFSIDSMVIT ESDVQRTVYP GSCHEDNIDG AIEFSGESGV KTETNMVKML EKQYQERLEE
EVAKVIVSMS IAFAQQTELS RISERKENAA SSKQSHALCQ QEQHFNEMKL PKGQADLQSF
EGTEVKFKEE FKPLSKELGE DGAEVLLPNN DDLAHILESK DRELTISEEM FSKDRTFIVR
ESIHDEILVS NMEASRQLML NEEQLEDMRQ ELVRQYQEHQ QAMELLRQAH MRQLERQRED
QEQLQEEIKR LNRQLSQRSS IDNENLVSER ERVLLEELEA LKQLSLAGRE KLCCELRSCS
TQTQNGNENH GEVEEQTFKE KELDRKPEDV PADILSNERY ALQKANNRLL KILLEVVKTT
AAVEETIGRH VLGILDRSSK VQPSGSLIWR SEAEASGKSC VHEEHIRVTD ESIPSYSGSD
VPRSDSSMWS KVTEEGTELS QRLVRSGFAG SEIDPENEEL MLNISSRLQA AVEKLLEAIS
ETSSQLEHAK ITQTELMRES FRQKQEATES LKCQEELRER LHEEARAREQ LAVELSKAEG
VIDGYADEKT IFEKQIQEKT DIIDRLEQEL LCAGSRLQEL EAERQQIQDE RELLSRQKEA
MKADAGPVEQ QFLQETEKLM KEKLEVQCQA EKVRDDLQKQ VKALEIDVEE QVCRFIELEQ
EKNAELMDLR QQNQALEKQL EKMRKFLDEQ AIDREHERDV FQQEIQKLEQ QLKLVPRFQP
ISEHQTREVE QLTNHLKEKT DKCSELLLSK EQLQRDVQER NEEIEKLECR VRELEQALLV
SADTFQKVED RKQFGAVEPK AELSLEVQLQ AERDAIDRKE KEDEMEKLGF AIKESDAVSP
QDQQVLFGKF AQIIHEKEVE IDRLNEQIIK LQQQLKITTD NKVIEEKNEL IRDLEAQIEC
LMSDQERVRK NREEEIEQLN EVIEKLQQEL ANIDQKTSVD PSSLSEEADS LKHQLDKVIA
EKLALEHQVE TTNEEMAVTK NVLKETNFKM NQLTQELCSL KREREKMERI QSVPEKSVNM
SVGDLSKDKP EMDLIPTEDA LAQLETQTQL RSSEESSKVS LSSLETKLLQ LESTVSTKDL
ELTQCYKQIQ DMREQGRSET EMLQTKIVSL QKVLEEKVAA ALVSQVQLEA VQEYVKLCAD
KPAVSSDPAR TEVPGLSQLA GNTMESDVSA LTWRISELES QLVEMHSSLI SEKEQVEIAE
KNALEKEKKL QELQKLVQDS ETKQRERERQ SRLHGDLGVL ESTTSEESGV FGELEALRAE
SAATKEELAN YKELAEKLQE ELLVKETNMA SLQKELSHVR DQLTEAEDKL SHFSEKEDKT
EVQEHGTICI LEPCPGQIGE SFASQTEGAV QVNSHTQTPQ IPVRSVGIQT HSQSDSSPEE
VAEIISRFTE KIEQMRELHA AEILDMESRH ISETETLKRE HCIAVQLLTE ECASLKSLIQ
GLRMPEGSSV PELTHSNAYQ TREVGSSDSG SDWGQGIYLT QSQGFDTASE GRGEEGETST
DSFPKKIKGL LRAVHNEGMQ VLSLTEGPCG DGEDYPGHQL SESWLEERRA YLSTISSLKD
FITKMQVQRE VEVYDSSQSH ENISDWRGEL LLALQQVFLR ERSVLLAAFK TELTALGTRD
AAGLLNCLEQ RIQEQSIEYQ TAMECLQKAD RRSLLSEIQT LHAQMNGRKM ILKREQESNK
PSQELLEHNV QQKQAQMLEM QAELGGMTER AAELQEQLSA EKLLVAELKS ELAQTKLELE
TTLKAQHKHL KELEAFRLEV KDKTDEVHSL NDTLANEQKK SRELQWALEK EKAKVGRSEE
RDKEELEDLK FSLEDQKQRN VHLNLLLEQQ KQLLNESQQK IESQRMLYDA QLSEEQGRNL
ELQVLLESEK VRIREMSSTL DRERELHAQL QSSGESGQPR PPLPSEDLLK ELQKQLEEKH
SRIVELLNET EKYKLDSLQT RQQMEKDRQV HRKTLQTEQE ANTEGQKKMR ELQSKVEDLQ
RQLEEKRQQV YKLDLEGKRL QGIMQEFQKQ ELEREEKRES RRILYQNLNE PSTWSLTNDR
TRNWVLQQKI EGETKESSYP KLIEMNGGGT DCNPELEMIR QKLQHVASKL QHLSQKAYNR
LQFETADDED FIWVQENIDG IILQLQRLTG QLREEPSIVS PSTPCGSLTE RLLRQNAELT
GHISQLTDEK NDLRNMVMKL EEQTRWYRQT GAGRDYSSRF AFSGGASIEA IIASEKEVWS
REKAALQKSL KRAEAEVCKL KAELRNDALL QHLSPDSENA ALKRIYGKYL RAESFRKALI
YQKKYLLLLL GGFQECEDAT LALLARMGGQ PAFTDLEVIT NRPRGFTRFR AAVRVAVAVS
RMKFLVRRWH RVTGSGSINI NRDGFGLNPG AEKTDSLYHS SGGLELYGEP RHTAYRSRSD
LDYPRSPLPF QNRYPGTPAD FNPGSLACSQ LQNYDPDRAL TDYITRLEAL QRRLGTVQSG
STPQFHAGMR R
//
