ID A0A5F9CFC9_RABIT Unreviewed; 1061 AA.
AC A0A5F9CFC9;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSOCUP00000032249.1};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSOCUP00000032249.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000032249.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000032249.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000032249.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000032249.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000032249.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02026135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A5F9CFC9; -.
DR SMR; A0A5F9CFC9; -.
DR STRING; 9986.ENSOCUP00000032249; -.
DR Ensembl; ENSOCUT00000046151.1; ENSOCUP00000032249.1; ENSOCUG00000006040.4.
DR GeneTree; ENSGT00940000157711; -.
DR InParanoid; A0A5F9CFC9; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000006040; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 5..57
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 62..181
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 117..180
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 189..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 741..778
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 274..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 112638 MW; AC695FD2B0BEF5ED CRC64;
MKEMIGGCCV CSDERGWAEN PLVYCDGHGC SVAVHQACYG IVQVPTGPWF CRKCESQERA
ARVRCELCPH KDGALKRTDN GGWAHVVCAL YIPEVQFANV STMEPIVLQS VPHDRYNKTC
YICDEQGRES KAATGACMTC NKHGCRQAFH VTCAQFAGLL CEEEGNGADN VQYCGYCKYH
FSKLKKSKRG SNRSYDQSLS DSSSHSQDKH HEKEKKKYKE KDKHKQKHKK QPEPSPALVP
SLTVTTEKTY TSTSNNSISG SLKRLEDTTA RFTNANFQEV SAHTSSGKDV TETRGSESKG
KKSSAHSSGQ RGRKPGGGRN PGTTVSAASP FPQGSFSGTP GSVKSSSGSS VQSPQDFLSF
TDSDLRNDSY THSQQSSSTK DVHKGESGSQ EGGVNSYNSL IGLPSTSAVI SQPKSFENSP
GDLGSSSLPA AGYKRAQTSG IEEEAVKEKK RKGNKQSKHG PGRPKGNKNQ ENVSHLSVSS
ASPTSSVASA AGSVTSSSLQ KSPTLLRNGS LQSLSVGSSP VGSEISMQYR HDGACPTTTF
SELLNAIHND RDDNSTLTKQ ELKFIGIYNS NDVAVSFPNA VSGSGSSTPV SSSHVPQQSA
GHLQQVGALS PSAASSATPA VATTQANTLS GSSLSQAPSH MYGNRLNTNP SMAALIAQTE
NSQTDQDLGD NSRSLVGRGS SPRGSLSPRS PVSSLQIRYD QPGNNSLENL PPVAASIEQL
LERQWSEGQQ FLLEQGTPSD ILGMLKSLHQ LQVENRRLEE QIKNLTAKKE RLQLLNAQLS
VPFPTITTNP SPSHQIHAFS AQTAPTTDSL NSSKSPHIGN SFLPDNSLPV LNQDLTSSGQ
STSSSSALST PPPAGQSPAQ PGSGVSGVQQ VNGVTVGALA SGMQTVTSNI PAVSAVGGII
GALPGNQLAI NGIVGALNGV IPTPVTISQN PAPLTHTTVP PNATHPMPAT LTNSASGLGL
LSDQQRQILI HQQQFQQLLN TQQLTPEQHQ AFIYQLMQHH HQQHHQPELQ QLQIPGPTQI
PINNLLAGTQ APPLHTATTN PFLTIHGDNA SQKVAVYFTG V
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