ID A0A5F9CL87_RABIT Unreviewed; 583 AA.
AC A0A5F9CL87;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=FERM domain containing 3 {ECO:0000313|Ensembl:ENSOCUP00000034368.1};
GN Name=FRMD3 {ECO:0000313|Ensembl:ENSOCUP00000034368.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000034368.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000034368.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000034368.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000034368.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008273119.1; XM_008274897.2.
DR AlphaFoldDB; A0A5F9CL87; -.
DR SMR; A0A5F9CL87; -.
DR STRING; 9986.ENSOCUP00000034368; -.
DR Ensembl; ENSOCUT00000045162.1; ENSOCUP00000034368.1; ENSOCUG00000014957.4.
DR GeneID; 100351545; -.
DR KEGG; ocu:100351545; -.
DR CTD; 257019; -.
DR GeneTree; ENSGT00940000158577; -.
DR InParanoid; A0A5F9CL87; -.
DR OrthoDB; 2912597at2759; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000014957; Expressed in smooth muscle tissue and 16 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17102; FERM_F1_FRMD3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF8; FERM DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..298
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 376..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 67223 MW; 9446487D0FFC1930 CRC64;
MKMIHFRSSS IKSLSQEMKC TIRLLDDSEI SCYIQRETKG QFLIDHICNY YSLLEKDYFG
IRYVDPEKQR HWLEPNKSIC KQMKSHPPYT MCFRVKFYPH EPLKIKEELT RYLLYLQIKR
DIFHGRLLCS FSDAAYLGAC IVQAELGDYD PDEHPENYIS EFEIFPKQSQ KLERKIMEIH
KNELRGQSPP VAEFNLLLKA HALETYGVDP HPCKDSTGTT TFLGFTAAGF VVFQGNKRIH
LIKWPDVCKL KFEGKTFYVI GTQKEKKAML AFHTSTPAAC KHLWKCGVEN QAFYKYAKSS
QIKTVSSSKI FFKGSRFRYS GKVAKEVVEA SSKIQREPPE VHRTNITQSR SSHSLNKQLI
INMEPLQPLL PCSREREEEL PLGEGVPLPK EDELPAPLTA SSPVKEAREF EDPPSEEEDK
MKEEPLTISE LAYNPSASLL PTPVDDDEID MLFDCPSRLE LEREDTDSFE ELEADENAFL
IAEEEELKEA RRALSWSYDI LTGHIRVNPL VKSFSRLLVV GLGLLLFVFP LLLLLLESGI
DLSFLCEIRQ TPEFEQFHYE YYCPLKEWVA GKVSLVLYML GCS
//