ID A0A5F9D0A9_RABIT Unreviewed; 730 AA.
AC A0A5F9D0A9;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Erythrocyte membrane protein band 4.1 like 1 {ECO:0000313|Ensembl:ENSOCUP00000039158.1};
GN Name=EPB41L1 {ECO:0000313|Ensembl:ENSOCUP00000039158.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000039158.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000039158.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000039158.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000039158.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000039158.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02060151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017197143.1; XM_017341654.1.
DR AlphaFoldDB; A0A5F9D0A9; -.
DR Ensembl; ENSOCUT00000053834.1; ENSOCUP00000039158.1; ENSOCUG00000004091.4.
DR GeneID; 100354933; -.
DR CTD; 2036; -.
DR GeneTree; ENSGT00940000158442; -.
DR OrthoDB; 5391231at2759; -.
DR Proteomes; UP000001811; Chromosome 4.
DR Bgee; ENSOCUG00000004091; Expressed in frontal cortex and 16 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17201; FERM_F1_EPB41L1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF24; BAND 4.1-LIKE PROTEIN 1; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 96..377
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..474
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 81639 MW; EB4FAE0ADA86DF5F CRC64;
MTTETGPDSE VKKAQEEAPQ QPEAAAATTP VPPAGHGHPE ANSNEKPAPQ QDARPAEQSL
DMEEKDYSEA DGLSERTTPS KAQKSPQKIA KKYKSAICRV TLLDASEYEC EVEKHGRGQV
LFDLVCEHLN LLEKDYFGLT FCDADSQKNW LDPSKEIKKQ IRSSPWNFAF TVKFYPPDPA
QLTEDITRYY LCLQLRADII TGRLPCSFVT HALLGSYAVQ AELGDYDAEE HVGNYVSELR
FAPNQTRELE ERIMELHKTY RGMTPGEAEI HFLENAKKLS MYGVDLHHAK DSEGIDIMLG
VCANGLLIYR DRLRINRFAW PKILKISYKR SNFYIKIRPG EYEQFESTIG FKLPNHRSAK
RLWKVCIEHH TFFRLVSPEP PPKGFLVMGS KFRYSGRTQA QTRQASALID RPAPFFERSS
SKRYTMSRSL DGAEFSRPAS VSENHDTGPD GTKREEDGES AGRRSEAEEG EVRTPTKIKE
LKFLDKPEDV LLKHQASINE LKRTLKEPNS KLIHRDRDWE RERRLPSSPA SPSPKGTPEK
AGEPVKAETM TVSSLAIRKK IEPEAMLQSR VSAADHTQVD GSALAGKEFM VTAPSITTET
ISTTMENSLK SGKGAAAMIP GPQTVATEIR SLSPIIGKDV LTSTYGATAE TLSTSTTTHV
TKTVKGGFSE TRIEKRIIIT GDEDVDQDQA LALAIKEAKL QHPDMLVTKA VVYRETDPSP
EERDKKPQES
//
