ID A0A5F9DAJ7_RABIT Unreviewed; 706 AA.
AC A0A5F9DAJ7;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=ClpB homolog, mitochondrial AAA ATPase chaperonin {ECO:0000313|Ensembl:ENSOCUP00000043292.1};
GN Name=CLPB {ECO:0000313|Ensembl:ENSOCUP00000043292.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000043292.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000043292.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000043292.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000043292.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000043292.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02008145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002708761.1; XM_002708715.3.
DR AlphaFoldDB; A0A5F9DAJ7; -.
DR SMR; A0A5F9DAJ7; -.
DR STRING; 9986.ENSOCUP00000043292; -.
DR Ensembl; ENSOCUT00000063624.1; ENSOCUP00000043292.1; ENSOCUG00000017356.4.
DR GeneID; 100341664; -.
DR KEGG; ocu:100341664; -.
DR CTD; 81570; -.
DR GeneTree; ENSGT00390000012961; -.
DR InParanoid; A0A5F9DAJ7; -.
DR OrthoDB; 35211at2759; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000017356; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF93; CASEINOLYTIC PEPTIDASE B PROTEIN HOMOLOG; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REPEAT 132..164
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 165..197
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 264..296
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 372..516
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 570..659
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 52..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 78799 MW; 0BDEDE0AC6A8FD16 CRC64;
MLGTLVLRTA PEPRLLLRLL RSPSLRSRGG ASGRTVTTGD RGEPQWLRVA AGGRPGPLPA
LLPGGGATTG GRRGRCAKTH GLAAAAWEHL PSPEGTLPGQ DSWNEVPNRA GLSMWALATA
LMVHCYSKSP SNKDAALMEA ARANNVQEVS RLLSEGADVN ARHKLGWTAL MVAAINRNDS
VVQILLAAGA DPNLGDDFSS VYKTAKEQGI HSLEDGGQDG ASWRVTNQWT SALEFRRWLG
IPAGVLVTRE DDFNNRLNNR ASFKGCTALH YAVLADDYRT VKELLDGGAN PLLRNEMGHT
ALDYAREGEV MKLLKTAETK YQEKQRKREA EERRRFPLEQ RLREHIIGQE SAITTVGAAI
RRKENGWYDE EHPLVFLFLG SSGIGKTELA KQTAKYMHKD AKKGFIRLDM SEFQERHEVA
KFIGSPPGYI GHEEGGQLTK KLKQCPNAVV LFDEVDKAHP DVLTIMLQLF DEGRLTDGKG
KTIDCKDAIF IMTSNVASDE IAQHALQLRQ EALEMSRSRL AENLGDVQIS DKITISKNFK
ENVIRPILKA HFRRDEFLGR INEIVYFLPF CHSELIQLVN KELNFWAKRA KQRHNITLLW
DREVADVLVD GYNVHYGARS IKHEVERRVV NQLAAAYEQD LLPGGCTLRI TVEDSDKQLL
KSPDLPSAQA EKRLPKLRLE LIDKDSKTHR LDIRAPLHPE KVCHTL
//