ID A0A5F9DS19_RABIT Unreviewed; 471 AA.
AC A0A5F9DS19;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Spliceosome-associated protein CWC27 homolog {ECO:0000256|ARBA:ARBA00040027};
DE AltName: Full=Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog {ECO:0000256|ARBA:ARBA00042090};
GN Name=CWC27 {ECO:0000313|Ensembl:ENSOCUP00000048349.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000048349.1, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000048349.1, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000048349.1,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000048349.1}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000048349.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAGW02031073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002714107.1; XM_002714061.3.
DR AlphaFoldDB; A0A5F9DS19; -.
DR Ensembl; ENSOCUT00000036930.1; ENSOCUP00000048349.1; ENSOCUG00000029499.2.
DR GeneID; 100355298; -.
DR KEGG; ocu:100355298; -.
DR CTD; 10283; -.
DR GeneTree; ENSGT00940000155967; -.
DR OrthoDB; 1328057at2759; -.
DR Proteomes; UP000001811; Chromosome 11.
DR Bgee; ENSOCUG00000029499; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd22288; CWC27_CTD; 1.
DR CDD; cd01925; cyclophilin_CeCYP16-like; 1.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR044666; Cyclophilin_A-like.
DR PANTHER; PTHR45625; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED; 1.
DR PANTHER; PTHR45625:SF6; SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 19..166
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
FT REGION 177..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..274
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 53581 MW; EB22C1791B08711F CRC64;
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD NTIFHRVVPG
FIVQGGDPTG TGTGGESIYG APFKDEFHSR LRFNRRGLVA MANAGPHDNG SQFFFTLGRA
DELNNKHTIF GKVTGDTVYN MLRLTEVDID DDERPRNPHK IKSSEVLFNP FDDIIPREIK
KPKKEKPEEE VKKLKPKGTK NFSLLSFGEE AEEEEEEVNR VSQSMKGKSK SSHDLLKDDP
HLSSVPAVES EKADAADLDD DAEDESAEDD EDIDGGEKNQ MRERIAKKLK KDTGTNVKSA
GEGEVEKKLI SRSEELRKEA RQLKRELLAA KQKKVENTAK AEKRSEEEEA APDGAVAEYR
REKQKYEALR KQQAKKGTSR EDQTLALLNQ FKSKLTQAIA DTPENDISET EVEDDEGWMS
HVLQFEDKSR KVKDASMQDA DTFEIYDPRN PVNKRRREES KKLMREKKER R
//
