ID A0A5G2QRQ0_PIG Unreviewed; 463 AA.
AC A0A5G2QRQ0;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Poly(A)-specific ribonuclease {ECO:0000313|Ensembl:ENSSSCP00000066752.2};
GN Name=PARN {ECO:0000313|Ensembl:ENSSSCP00000066752.2,
GN ECO:0000313|VGNC:VGNC:110695};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000066752.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000066752.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000066752.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000066752.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR AlphaFoldDB; A0A5G2QRQ0; -.
DR Ensembl; ENSSSCT00000070848.2; ENSSSCP00000066752.2; ENSSSCG00000007878.5.
DR VGNC; VGNC:110695; PARN.
DR GeneTree; ENSGT00940000153167; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000007878; Expressed in mesenteric lymph node and 43 other cell types or tissues.
DR ExpressionAtlas; A0A5G2QRQ0; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 2.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 262..339
FT /note="Poly(A)-specific ribonuclease RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF08675"
FT REGION 409..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 53002 MW; 181C3F42CC4CDDFE CRC64;
MEIIRSNFKS NLHKVYQAIE EADFFAIDGE FSGISDGPSV TALTNGFDTP EERYQKLKKK
ERYIVISKVD EEERKRREQQ KQAKEQEELK DAVGFSRVIH AIANSGKLVI GHNMLLDVMH
TVHQFYCPLP ADLNEFKEMT TCVFPRLLDT KLMASTQPFK DIINNTSLAE LEKRLKETPF
NPPKVESAEG FPSYDTASEQ LHEAGYDAYI TGLCFISMAN YLGSFLSPPK IHVSARSKLI
EPFFNKLFLM RVMDIPYLNL EGPDLQPKRD HVLHVTFPKE WKTSDLYQLF SAFGNIQISW
IDDTSAFVSL SQPEQVQIAV NTSKYAESYR IQTYAEYVGR KHEEKQMKRK WAEDGWKEVE
RKRSNSQCLP YAPQNHYYHA DGLTATSTVR KRNLSPCQAE ADLEARVSGE LSDTELEQTD
PCAESHSEGR KKAKKLKRMK KDLSPTGSIT DSPAKLFEVP DTW
//
