ID A0A5J4N6Y8_9TREM Unreviewed; 332 AA.
AC A0A5J4N6Y8;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 9.
DE SubName: Full=Cathepsin F {ECO:0000313|EMBL:KAA3671233.1};
DE Flags: Fragment;
GN ORFNames=DEA37_0004368 {ECO:0000313|EMBL:KAA3671233.1};
OS Paragonimus westermani.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus.
OX NCBI_TaxID=34504 {ECO:0000313|EMBL:KAA3671233.1, ECO:0000313|Proteomes:UP000324629};
RN [1] {ECO:0000313|EMBL:KAA3671233.1, ECO:0000313|Proteomes:UP000324629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IND2009 {ECO:0000313|EMBL:KAA3671233.1,
RC ECO:0000313|Proteomes:UP000324629};
RX PubMed=30520948;
RA Oey H., Zakrzewski M., Narain K., Devi K.R., Agatsuma T., Nawaratna S.,
RA Gobert G.N., Jones M.K., Ragan M.A., McManus D.P., Krause L.;
RT "Whole-genome sequence of the oriental lung fluke Paragonimus westermani.";
RL Gigascience 8:0-5232231(2019).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA3671233.1}.
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DR EMBL; QNGE01006940; KAA3671233.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5J4N6Y8; -.
DR Proteomes; UP000324629; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF959; CATHEPSIN F; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000324629}.
FT DOMAIN 36..95
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 119..330
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAA3671233.1"
SQ SEQUENCE 332 AA; 37223 MW; 2480E1D0FFD1460A CRC64;
PEKRVQLFAV GYLVVLVGCT FAVHTARVPD NARELYEQFK RDYGKVYANE DDQKRFAIFK
DNLVRAQQYQ MQEQGTAKYG VTRFSDLMHN TAKEFATKYL GSRISGKVHR VQLNDLKAAP
ASVDWRDKGA VGPVENQSVC FSCWSFSVAG NIEGQWFLKT GQLVSLSKQQ LVDCDKLNYG
CEGGYPTEAY KEIKRMGGLE LEEDYPYVAE EQACELDESK LLAKIDDSVV LEIDEEKQSA
WLAEHGPTSV LLNAAPLQYY EFGISHPSKD RCPSDDLNHA ALSVGYGTED GVPYWIVKNS
WGATWGEDGY FRIYRGDGTC GIDQSVTSAI IH
//
