ID A0A5J4NWJ0_9TREM Unreviewed; 3829 AA.
AC A0A5J4NWJ0;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 08-NOV-2023, entry version 14.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|EMBL:KAA3679884.1};
GN ORFNames=DEA37_0014429 {ECO:0000313|EMBL:KAA3679884.1};
OS Paragonimus westermani.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus.
OX NCBI_TaxID=34504 {ECO:0000313|EMBL:KAA3679884.1, ECO:0000313|Proteomes:UP000324629};
RN [1] {ECO:0000313|EMBL:KAA3679884.1, ECO:0000313|Proteomes:UP000324629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IND2009 {ECO:0000313|EMBL:KAA3679884.1,
RC ECO:0000313|Proteomes:UP000324629};
RX PubMed=30520948;
RA Oey H., Zakrzewski M., Narain K., Devi K.R., Agatsuma T., Nawaratna S.,
RA Gobert G.N., Jones M.K., Ragan M.A., McManus D.P., Krause L.;
RT "Whole-genome sequence of the oriental lung fluke Paragonimus westermani.";
RL Gigascience 8:0-5232231(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA3679884.1}.
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DR EMBL; QNGE01000601; KAA3679884.1; -; Genomic_DNA.
DR Proteomes; UP000324629; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000324629};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3805..3823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1975..2132
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 2158..2355
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 482..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1190..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2839..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3489..3533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1190..1209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3497..3533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3829 AA; 418283 MW; 2E27AC1F50ECD1BC CRC64;
MEQNKECLIN VSRCKFSLVV SGLTKMLQSI GGMPVYGPDA ERNFCDSLLI VLETLEKCLT
CVGSPLRFFS FFLYLQQTRD TSRLDETILV KNVLQELFKV RNLVLNFMNL TSDNVKMYNQ
LINLVSQVLY ALSTQYFNAV FNRISNCLAL AAQDESSGDL ASELELIQHL NLDMRKLARL
IFEICNRFRS LKKPTWLHLA VYLERVRKAL SSHGHGSGSS KPVLIEAALL AAVNLCKAST
FININDRNNT LFILVHSVYA DLQPRLPWWP DVSPFYSKSP EIRTMFLETL NRVNHHPPIR
IAQSLTFRDK MNLRIKDKTE DNLMGKYNLL LNMVRLINAN PLLMLYCPQT RPSPDAQKAT
FELMNGLMSL IQQSTMSELA QEAMDALLCL HQPANIRLWN LHSPAQAFWE ISPQLLYSIA
QNLLNRNIPN SCDVLKWLRE ILICRVNFLQ QNCDCINIPG CLPDVTTKTD SLSTMTTSAA
IDTGPFESES SQSTNPYATA SKETSAIRRQ PGGGQQQFTA TDVNTLLGPL GVNSKRNRMA
LIKLETVFFT YLWSLDLEAV LTSMSCFRLL CREAELWSND VASAMVASLP EMDRNALLYG
CDSCSNLTTT TLAMHRELKE WDFKNAGPLP TAPGSQLVSA TQKNVESTRA QDLLGQLYLP
HGVGSSADAA RAQLHSSLTH LAPQTKNTTF EIDPRNRVSN FGSCIALCDC GCPLCAPSSY
ISAGANNTKA YTTTSIADVQ PTISVSTTFC RHQFELCPAS SVKSSTSPTH MMTKPGRSGT
ASTPRYRSPC CETSALRARS DCRLPDLLPV YCAYAEIADH SRSIVTTGRA HLQKQILNLL
RKINHQTQGN KLAWEHTYMI WQRSTKFLIN YPKSKVSASA GGTEDASYDS PGNHPPGNAG
ISGLNASVGS SSVIGDSSSI VSELDSIAIS GDSFTGLVRD KSGMPHNLGT NSGSLFGLTN
HSINVCGLSS SSSLQAPNTI VGGSGSNVYG VSGSGVSNAT RYLAVKRRSS QQPTASDHEI
EDVLNEWANM TGFLCALGSV ALNSTASQSL PAHPVFQSTG CSHCCCDRRL WHQFARHSSS
KPYQPDTTQS TWLSTTGAQT TSNETPSSYS ACNPCFTDET GRRPSQQITS STSTLSTTLD
VDHRTLESSV DPDSVSEVLF DLDSPRGITS KQNNLFTESL KQLRDSKLQH HLSSSALQPT
QTCTHQRHQL AQHHSYHPSP DRSSTVTRRY PTEHYGFPDS ESRYACATVN PNLSSSGSGA
KSALCLSDTD PLRPSKICPV HLFCTVEGPT RRMSLAQTTS FSQDHQFSPV AQYIGNLLLL
ISCQHEKFGH QIQKHVKEAI GNELNPLIYP ILFDQLRAHV DACFSGQGQQ QVVVTETNTL
FVENVIFIMR SILDKRAGKS MDRQNGHLEM ISIESLMLNI VRYVRHLECV HSLQIKIKVC
QLVQKMMARR EDLTFRREMR FRNKLVDYLC DWVMGSSYHL NLTTPSSHTS NLISGMGGPM
TGLNSGIIGQ GVNVQGQMEL MSGGTSTHGQ FSIIGPNGCV MSGISVHDLN ALSGNLGPGY
SFVFTGTASN TGFGTGNSST ITGIPMSAQQ TFPTPLNLVN PGSAVGYSEQ TGSYSSVGAD
QLGLAYTPGH VWLSQTSVAN TVPSFTVNAA NSVAGQPNLM FFLTSSASVE SSNSQSGTQH
VNDAIFAGQC AAATGTSTGL GVTGHTMGLV SAVGPVGKLH TLPLLAGSIG LPTSITSHQT
QNPNAASQLS LPSTVALPAS STSDSMGTKL APDPNITSAY NPSASAVAYN MAALGPNATG
PAGLSVQTAM QTRELDLACM GAVAALLQGM PLQPEETDRG DLMDAKSHLF AKYFTLFMNL
LNDVADDREK RPEVRQNNTA LRNVTVQAMS NLLNANIESG LVHAIGLGYH RDPQSRAAFM
EVLTKILQQG TEFETLAETA LAERYERLIG LVTMIGENGE LPIAMALSQV VQGANMDELA
KVLVTLFDAK RLLYQLFWNV FSKELEAVDS MQTLLRGNTM SSKIMNYCFK QFGQDYLQST
LGPALMELVR RDAGGSGSLA ESACLESVAV YTGSEAATGP NDYNQPQQRT SCMTKPSYEV
DPRRLQPGEN LQENQQNLIY ATELLYGRLI ASPERWSYME TASNRLEDWV LRGYQFRDSE
EFKRLKSLNV FYQAGTSRFG NPVFYYIARR YKSQEYQRVE YPLIICLVSV TLDAYKNKPF
ELVVDFTHAS AENRFKASLL LHPFILLCEQ RFCHSPFHEA VVLLSSMIFF GSSQLHSFAL
AFQNDLLSKW ASIIGPVLRE YLVAAYIYNC NSWVREYTKI HDRFFAPIKG SRKLIFIDHP
TRLNEYIEPD QQRLPGGTLV LEEDLRVFNN ALKLSHKDTK VAIKVCTNAI QVTSTEKSKV
LGISVILNDV YYASEIEEVC LVDDNQFTLT ISNDSGPLSF IHDACDSIVQ AIIHIRTRWA
LSQPDTHTMH TKLRPRDVPG TLLNITFNLK IEGQLLETSG LCIPGNNTLF IAEISKRLAQ
LEPHLTLEFL DECIQGFSRS SIEMKHLCLE YITPWLRNLT RFCRSDDAKR QKVHSIIDKL
ITLTIEEEQM YPSIQTKIWG NLGQVPQLLG LVLDSFIQRS VSCGLGSLQA EIMADTSVAL
AAANVQLVSK KVLSKLCRLI EKTCSAPTTL LEQHQFWPEI APMLRYLLML SFNNCLDIRT
HLPRLFHIAT LLVCTGPISL RASMHGFVIN VIHSLCTSAL AKQLSEKTVQ QLCQLLAEFT
LPKFYEVFGI QHCKCAPISA FPHFRPGERS GLMATGSVNP SVVAPTACYS PATQTAATGL
FAGQPHLFHS QGSSGSISSS CSGNSSSTHG SSVPLSVTDS LPRTSGIRSS TTAAATGGVT
GRGSNFHAVA LRKPTSSECP SLPAIVLVDE DSCGTNRHTN PSDSGAKVIG DPCSEPSTDS
PQHLVFNSTF SANVGNYSES AIFPLITPSS RAESGVFGLN VQCCSGASSS STYLRTEGSG
MTVNPSGACL HSMLVPTSYG LVQTVGQPMN MRTDGTDKPG RLSLNSLEFL TDTLLEVMSL
VIKEVPEFMH WLDQWTHLAR KFAFQHNPAL QPRAIIVLGC ICKGFTDTDI KQLLRILSRA
LESYANELDM EKDLRHRTGD TGQAELYLIE AIIICLTRLL PLLPADSETH QPLFWVALGV
LQLDEVSLYA AGLTLLEQNL ITLDEHGTFE RDTLETVMMR CREQFILQYK QMDQAVGLSF
RDSFHFALVG HLLKGFRHPV LTTVARTVRV LNTLLGIVAK PYNRDKYQVT KDSVAYLAAL
LPVSEEVRKR CRLKFRIPGT LVGPGDQQQP IIHSYTVTPV SGLSATVSGF PPKGVSALGD
WYGSTESLYE PTVRHVPTAP RASGAVSLLR SLLPNSHVTS LSGRLVRMRP EAATNVLGHT
VDNLSQPHHR SLQTRITTNS VESRFHPQRP TGLSGATEGL RSRSIDCCAS TTGPNSADGS
APISKAAGGP TPIEASPSVG TFLSPTGPIK DTTYSAGPSA ELSGDAPQQQ QSEKKIGDNF
LLDPNVLTDE ALQALTIAVL TTLVRYATDE NESRVLYEFL ADASMVFPRV FPVIHSLLDS
KINYVLTHCH DQKILSAVQS IIQNMISNGE TSVQQLHYLQ SIGFGGLWRF SGHFSKANQN
ADSAQLFVNF LEVLIDSHLP GEDLRTSYTP VLGLSGTSHA GHLSSSSSLS LSSIHGPLAS
TDALLNGAEA NSSVPTPLSP TLAGVPCPVS TTQKVTETVP LELSHSYHTG PAGNDEESGL
TGVVQPSVMS VASFKSTKVT TCKILFVYSA AVILVPISSL YLASNTVAY
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