ID A0A5J4Z793_PORPP Unreviewed; 763 AA.
AC A0A5J4Z793;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=FVE85_6790 {ECO:0000313|EMBL:KAA8499205.1};
OS Porphyridium purpureum (Red alga) (Porphyridium cruentum).
OC Eukaryota; Rhodophyta; Bangiophyceae; Porphyridiales; Porphyridiaceae;
OC Porphyridium.
OX NCBI_TaxID=35688 {ECO:0000313|EMBL:KAA8499205.1, ECO:0000313|Proteomes:UP000324585};
RN [1] {ECO:0000313|Proteomes:UP000324585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP 1328 {ECO:0000313|Proteomes:UP000324585};
RX PubMed=31645564; DOI=10.1038/s41467-019-12779-1;
RA Lee J., Kim D., Bhattacharya D., Yoon H.S.;
RT "Expansion of phycobilisome linker gene families in mesophilic red algae.";
RL Nat. Commun. 10:4823-4823(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA8499205.1}.
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DR EMBL; VRMN01000001; KAA8499205.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5J4Z793; -.
DR Proteomes; UP000324585; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000324585};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..763
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023884317"
FT TRANSMEM 702..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..243
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT REGION 740..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 84095 MW; 8E5813F20DDCDF62 CRC64;
MRATVRQLIW LAVFCAWVLV SESGRAKAQT QCSFDEYERL TPLEGLDKIE PFRKRCWTAR
TDDVGVCVQF QDRDGVYGCA QCGEDVLSSP MLFFSDAAQL IDFATDEQAT SVFVVMISIE
LYTSAQVMNT LANNPGRIVA LIIDRDQCVD GGSGSSVLPY PPVDMFSPVQ PFPNKQFSTT
PDSAYVWNPP GNSISFDYFP FNVFFVNDTL ATFLRFQSLR FLGNTFTEQP GFPRQVVESV
GQMWSCDEDA NTCLNKSTCI PIGQQSVYSS VGKMDPNLEI VSVSAQFDST AFSREDFGYG
ASARILAVGS VLAVAESFFQ YRIDPEGGAS RGLVRLPLFL LFTAEEWGFS GSRFFLNDVA
NFQCEAPLNI SQGIIGCRTP YRPSAAFQNL NADNWLGDID VSQLGSSNGT FYLHSLNTSV
NDIVLRNVKA AFGSTLLQDA VQAGGNFPPE SAQSFVQVFG DAFSSLFIGD YDAQFKAPFF
DSMFDNITQL TDADYASACD VARGVTKSLI QLTYLDADSV PIVNCSIIPE VVRCLTGNFT
DCELARRFVE PEVFALITDS SVPESNFPLL YQPLPVILNT EPHWVAKATF LLSYLGYYNA
FNQTGVYCES FADCRDVSLE ANNDFQNLQP QDALDVYCSN QQCVVTSAWF HPALGVGLET
ANDDYTLYKI NESAPSSAAT FSQSLYDSDI GICSFTQDAY SYQAAILVVG IMLWPVCAIP
CLIHWWLERK RYQGAELLPT TAPKEPARST EPSAPAPPVT RSN
//