ID A0A5J5AM06_9ASTE Unreviewed; 635 AA.
AC A0A5J5AM06;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=F0562_005380 {ECO:0000313|EMBL:KAA8530686.1};
OS Nyssa sinensis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; Cornales; Nyssaceae; Nyssa.
OX NCBI_TaxID=561372 {ECO:0000313|EMBL:KAA8530686.1, ECO:0000313|Proteomes:UP000325577};
RN [1] {ECO:0000313|EMBL:KAA8530686.1, ECO:0000313|Proteomes:UP000325577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J267 {ECO:0000313|EMBL:KAA8530686.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAA8530686.1};
RA Yang X., Kang M., Yang Y., Xiong H., Wang M., Zhang Z., Wang Z., Wu H.,
RA Ma T., Liu J., Xi Z.;
RT "A chromosome-level genome assembly of the Chinese tupelo Nyssa sinensis.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR EMBL; CM018043; KAA8530686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5J5AM06; -.
DR Proteomes; UP000325577; Miscellaneous, Linkage group lg2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000325577};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..635
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023804001"
FT TRANSMEM 605..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..204
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 635 AA; 68776 MW; BD1B10A3353F2D3E CRC64;
MAAKHVYVLL WFIAPFVLSF SASEELNALE SVPDLEKSMY VVIDGYPCVR LLNLSGEIGC
SNPGRDKVVA PIVRFKNADE LVQLSAILVS LNDFENFFLR VSNDSNFAKN VGGVLVESGT
EIQNELKGFS PAEKFPQAKF APYRGINYEW NPIGSGIMWN TYNFPIFLLS QSSTLTLQEL
AVKNEKSKKA YNAKVAEFDL VMQTTKAGTH DSESCLKEET CLPLGGYSVC LGADSPISGL
ISLLAAVDAL SHVDGLDDLN KQLVFVVFTG EAWGYLGSRR FLLELDRHSD AVYGLNNTLI
DMVVEIGSVG KGFSQGVKNL FAHTTGVSSA TNKTLTALQR ARDSLQSEGI KISTANASNP
GIPPSSLMAF LRKNSQTSGV VLEDFDTVFT NKFYHSHLDD LSNINSSAIV AAASLVARTL
YVLASDGKDL STSALSAINI NASLVEELLG CLLNCEPGLS CGLVKHYISP TSTCPSHYVG
VLLGEPTFTP YAGYVGDVPR FLWNFLADKT SIPTENATSC PKNCSNTGEL CIKAETDGKG
VCVVSTTRYV PAYSTRLKFE SETWKVLPIN STDPMGLADP VWTESNWGVI ALRVYTVQDA
AYDRLILLGG FSITVLAYFG IVITRACIAK ALKQD
//
