ID   A0A5M3X9Z4_9ACTN        Unreviewed;       299 AA.
AC   A0A5M3X9Z4;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000313|EMBL:GES15663.1};
GN   Name=dapA_3 {ECO:0000313|EMBL:GES15663.1};
GN   ORFNames=Amac_092610 {ECO:0000313|EMBL:GES15663.1};
OS   Acrocarpospora macrocephala.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Acrocarpospora.
OX   NCBI_TaxID=150177 {ECO:0000313|EMBL:GES15663.1, ECO:0000313|Proteomes:UP000331127};
RN   [1] {ECO:0000313|EMBL:GES15663.1, ECO:0000313|Proteomes:UP000331127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16266 {ECO:0000313|EMBL:GES15663.1,
RC   ECO:0000313|Proteomes:UP000331127};
RA   Ichikawa N., Kimura A., Kitahashi Y., Komaki H., Oguchi A.;
RT   "Whole genome shotgun sequence of Acrocarpospora macrocephala NBRC 16266.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GES15663.1}.
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DR   EMBL; BLAE01000081; GES15663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5M3X9Z4; -.
DR   OrthoDB; 3175637at2; -.
DR   Proteomes; UP000331127; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365}.
FT   ACT_SITE        138
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        167
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         209
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   299 AA;  31733 MW;  242E9EE43454B1EB CRC64;
     MQPTTIWGGI FPAALTMFDA HGRLDEDASA AHVDWLIGQG AHGVVVAGTS GEFISLSGRE
     RRRLFEVTVK AAAGRVPVIA GTGAFSTTET VELTQGAAEA GASGAIVILP YYQRPHRDEV
     LAHFRAVGRA AEIPIMVYNN PANSGTEPLT AADLATLYVE GAAQAVKSTF PTVHQVHEAR
     AATDEGFRVF YGSFMAPLEG MAGGAHGWVS GILNVATPDA VALWEAVQRG DLPAARAAWA
     RILPIKYLYT RQPLGPVSDL AIYREMLAMR GLPGGHSRAP LLPLTSDQRE TLARLLAES
//