ID A0A5M6CER6_9BACT Unreviewed; 948 AA.
AC A0A5M6CER6;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:KAA5533688.1};
GN ORFNames=F0919_14220 {ECO:0000313|EMBL:KAA5533688.1};
OS Taibaiella lutea.
OC Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC Taibaiella.
OX NCBI_TaxID=2608001 {ECO:0000313|EMBL:KAA5533688.1, ECO:0000313|Proteomes:UP000323632};
RN [1] {ECO:0000313|EMBL:KAA5533688.1, ECO:0000313|Proteomes:UP000323632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KVB11 {ECO:0000313|EMBL:KAA5533688.1,
RC ECO:0000313|Proteomes:UP000323632};
RA Chhetri G.;
RT "Genome sequence and assembly of Taibaiella sp.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA5533688.1}.
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DR EMBL; VWSH01000003; KAA5533688.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5M6CER6; -.
DR Proteomes; UP000323632; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF34; ZINC PROTEASE PQQL-LIKE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000323632};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..948
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5024342508"
FT DOMAIN 57..174
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 213..393
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 707..872
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 948 AA; 106675 MW; 550D6B2E3FE37B03 CRC64;
MFKNFLSKAA LACLFTSATF SAYVVSAQTS KTEKLPVDPK TKIGKLPNGL TYYIRPNSKP
EKKVELRLIL NAGSILENDN QQGLAHFMEH MNFNGTKNFP KNKLVDFLQS IGVEFGADLN
AYTSFDETVF ILPIPTDKPG NLESGFQVIE DWAHNANLTE QDINDERNVV LEESRLGKGA
DDRMSKKYLP KLFAGSHYAN RLPIGIDSIL RTFKPEAIRA FYHDWYRPDL MAVAVVGDIT
VPEAEALIKK HFGGMTNPAN ERKRNAFEVP TYPEASAMVL TDKEATNYAF QLFFPVKKET
VRITLDDYRS NLIQTLFTQV LNRRLQELTQ SATPPFSFAS TFANSFLRGY ESFGVFGMPA
DDIQTSVNAI VGELVKAETY GFNNSELEIV KKQFQSSVEK SYNERDKTPS SRLVDEYIRN
FLTKEPIPGI ENEYNYVKTM LPTITINEVN AEAKKWLNKG NYDKYFALIT GPDAKKMPVP
TDIELKEMVD NAFQQKVNAN EEKKVATSIL DKEPVAGKIV SEATDKELGA TTFTLSNGVK
VTIKKTDFKS DEITLEAVKK GGYNNYGAAD KSNTKFLPDV IEAMGYGNFT PTQLEDLLSG
KTVSLVPEMD DIYNEIKGNS SVKDFESLLQ LTYLQLTSPR TDEDLFKGFI NTQKTQLQFL
SQNPQIAFID TMLKTVYHND PLTPIQVPTV QDVDKIDMNR VVDIYKNEFS NADGLHFFIV
GNIDESTIRP LLEKYIASLP ANGSQPTMKD NGLRPISGNN SLVFNKGEEQ KSLVLMMNRG
ELPYTESLAL QTQMIADILS ISVIENVREK MGAIYGGGFQ GQFEQYPYAH YSLSGYFPCG
PENVDPIMKE ANKEIEDLKK NGPSQKDLDK VKLAIVEKRK ENIKTNTYWN NKLEQLLFWN
ESKDRFLNFE TELNKITVSD IKATANKLFD GKNSFNAVLQ PAVVKTKG
//
