ID A0A5N0UMF9_9PSEU Unreviewed; 304 AA.
AC A0A5N0UMF9;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Dihydrodipicolinate synthase family protein {ECO:0000313|EMBL:KAA9150646.1};
GN ORFNames=FPZ12_040790 {ECO:0000313|EMBL:KAA9150646.1};
OS Amycolatopsis acidicola.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=2596893 {ECO:0000313|EMBL:KAA9150646.1, ECO:0000313|Proteomes:UP000319769};
RN [1] {ECO:0000313|EMBL:KAA9150646.1, ECO:0000313|Proteomes:UP000319769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K81G1 {ECO:0000313|EMBL:KAA9150646.1,
RC ECO:0000313|Proteomes:UP000319769};
RA Teo W.F.A., Duangmal K.;
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA9150646.1}.
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DR EMBL; VMNW02000114; KAA9150646.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N0UMF9; -.
DR OrthoDB; 3175637at2; -.
DR Proteomes; UP000319769; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR020625; Schiff_base-form_aldolases_AS.
DR PANTHER; PTHR42849; N-ACETYLNEURAMINATE LYASE; 1.
DR PANTHER; PTHR42849:SF1; N-ACETYLNEURAMINATE LYASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00666; DHDPS_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000319769};
KW Schiff base {ECO:0000256|ARBA:ARBA00023270}.
FT ACT_SITE 138
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 166
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 207
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 304 AA; 31839 MW; DFA02213EEBD55DE CRC64;
MTDPVLDHGV VPPVLTPLTP ERELDVTSLE RLVGFLLDAG VHGLFVTGSS GEAAYLPDDV
RYRVLEVTAG VAAGQVPVLA GIIDTSTPRV IQHAYAAKAH GAQALVATAP FYAPTAPPEF
PGHFRAIRAA VDLPLIAYDI PVSVHAKLSP DLIAELAADG TLDGLKDSSG DLDALRAVLE
TAPGFRVFTG SETMADVALF LGAQGLVPGL GNVDPHGYVR LYEAARRGDW VAAGEEQRRL
RRLFTLITVG GSRMGRYSSA IGAFKEALVA RGILAHGTTS VPMIPLDGTE RAAVRARLAE
AGLG
//
