ID A0A5N4B2K2_PHOPY Unreviewed; 1000 AA.
AC A0A5N4B2K2;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPYR_00802 {ECO:0000313|EMBL:KAB0803832.1};
OS Photinus pyralis (Common eastern firefly) (Lampyris pyralis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia; Elateroidea;
OC Lampyridae; Lampyrinae; Photinus.
OX NCBI_TaxID=7054 {ECO:0000313|EMBL:KAB0803832.1, ECO:0000313|Proteomes:UP000327044};
RN [1] {ECO:0000313|EMBL:KAB0803832.1, ECO:0000313|Proteomes:UP000327044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1611_PpyrPB1 {ECO:0000313|EMBL:KAB0803832.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KAB0803832.1};
RX PubMed=30324905;
RA Fallon T.R., Lower S.E., Chang C.H., Bessho-Uehara M., Martin G.J.,
RA Bewick A.J., Behringer M., Debat H.J., Wong I., Day J.C., Suvorov A.,
RA Silva C.J., Stanger-Hall K.F., Hall D.W., Schmitz R.J., Nelson D.R.,
RA Lewis S.M., Shigenobu S., Bybee S.M., Larracuente A.M., Oba Y., Weng J.K.;
RT "Firefly genomes illuminate parallel origins of bioluminescence in
RT beetles.";
RL Elife 7:e36495-e36495(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0803832.1}.
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DR EMBL; VVIM01000001; KAB0803832.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N4B2K2; -.
DR InParanoid; A0A5N4B2K2; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000327044; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 3.10.620.30; -; 1.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR018026; DNA_repair_Rad4-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR NCBIfam; TIGR00605; rad4; 1.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000327044}.
FT DOMAIN 732..784
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 786..842
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 849..923
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 114901 MW; 9D309053EA3809DA CRC64;
MRRSTRRKKP LAIVNDEDED IAEEISAVEQ NKKMGDAQDS SSDSDIENYL QPVDKLDLDS
SFFQIQKSPE IQSFESIEKD IFAGTNRLSD MDSDESDPEQ EPTPTTSKLN FDQLHSYTNK
LDQMKQAIQN YKTKQKVADA KAKPHSDNIS DLLALGEMQV DNPTDNHSLH SSDFHSCSEV
EDNDWEEVED KLTKPSTSLV KDGIQITVSL PDTMKKKKGV DLLASLKRRL NRIKKEHQVL
IHKVHLLCWI AHGNYINKNL NSETILGLAL SLIPSQHCYP PDRTDLTYLE QILNWYNKVM
DLSEKLVSKQ WSLEKVLTLQ LTRRQAYNKK MFTYIFICIL RALGIQCRLV LSFQVLPLRP
LSNELHSLST KANNKNEVKT DHKTTSKISE KNEPKQDTTR KKNSKEQIEK KTTENKKAKS
DKVEKVGSGN STKQSTEKTS TSKLPSSTTQ RGKTNPKQSK RQLAQLDGAN DSSEAEKSTK
PNLKNLSKES KRQCPKNHPK RLKKTPNYRE THSSSSEEER EEKTQRLINL QNLKDKLKPR
SKASKSSDVK NEIVSIVKTR IKKEKEASRS KLAKSRQSKG KSEEDSDYAP DPIHKKYDSD
DDFQQDKVKV KKRIEVKRNQ PESENATKGM DVWVEVYLEA EEKWISVDVG KNQVHCVNQL
YSRASHPVSY VIAWNNNNSI KDITQRYCTN WNTTTRLLRV DAKWWSATLK PYTGVKTARD
KEEDEELAQL QLDKPLPSTI SEYKNHPLYV LKRHLLKFEA LYPPDLPPVG FIRNEPVYPR
ECVHVLHSRE IWMKEAKQVK PAQQPYKIVK ARPKYDKLSG KVITDLPLEV FGIWQVEDYI
PPTAENGVVP RNAYGNVELF KPCMLPKGTV HLQLAGLNKV ARKMGIDCVP AVVGFDFHSG
WNHPTYDGFV VCEEQSEALV AAWFQDQEEQ EKKELEKIEK RVYGNWRKLI KGLLIRERLK
KRYDYGEPSS QGDSKGKKRK QKAAKFVTKK RRICSNSESD
//
