ID A0A5N5G769_9ROSA Unreviewed; 986 AA.
AC A0A5N5G769;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN ORFNames=D8674_006151 {ECO:0000313|EMBL:KAB2606434.1};
OS Pyrus ussuriensis x Pyrus communis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Pyrus.
OX NCBI_TaxID=2448454 {ECO:0000313|EMBL:KAB2606434.1, ECO:0000313|Proteomes:UP000327157};
RN [1] {ECO:0000313|EMBL:KAB2606434.1, ECO:0000313|Proteomes:UP000327157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 {ECO:0000313|EMBL:KAB2606434.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAB2606434.1};
RA Ou C.;
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000327157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wang F., Wang J., Li S., Zhang Y., Fang M., Ma L., Zhao Y., Jiang S.;
RT "A de novo genome assembly of a pear dwarfing rootstock.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAB2606434.1, ECO:0000313|Proteomes:UP000327157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 {ECO:0000313|EMBL:KAB2606434.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAB2606434.1};
RA Wang F., Wang J., Li S., Zhang Y., Fang M., Ma L., Zhao Y., Jiang S.;
RT "A de novo genome assembly of a pear dwarfing rootstock.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Acts as an
CC endogenous post-transcriptional gene silencing (PTGS) suppressor.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB2606434.1}.
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DR EMBL; SMOL01000559; KAB2606434.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5G769; -.
DR Proteomes; UP000327157; Chromosome 11.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR PANTHER; PTHR12341:SF75; 5'-3' EXORIBONUCLEASE; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 2.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Reference proteome {ECO:0000313|Proteomes:UP000327157}.
FT DOMAIN 1..252
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 314..759
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT REGION 261..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 112881 MW; E62B435A187380F9 CRC64;
MGVPSFFKWL VNKYPKVVVK AIEGQREESP NPNPTNLEFD NFYLDMNGII HPCFHPEADD
DDDGGLLPPA NFEEVFINIF EYIDILFNIV RPRKLLYLAI DGVAPRAKMN QQRMRRFKSA
KDAEVAEVEE EKLRRQFELE SKQVLPKQRS EVSDSNIITP GTEFMHKLSK ALRNYISLRL
SNDLGWRDIE VILSDANAPG EGEHKIMSFI RSQRNLPSYD PNTRHCLYGL DADLVMLALA
THELHFSILR EDVLHNEQRR TNCESIQEKG PSSGKSDNKK RSMLKKPFQF LHVWILREYL
ELDLKIDDPP ENFKFDLERI IDDFIFMCFF AGNDFLPHMP TLEIHEGAID LLMTVYKKEL
KSLGGYMVDM LRVNDKKSGY VKLSRVEKFI LLVGSYEDKI FKKRSEIRDR KLRRLCYYND
SLEEEVDTGS SITGLSNTHA FFSGEELEVW SDGTSDIMHS QVVENTKELK KKLKDNIRRK
SDLFNNGDLG SDKVRFAVGG YKERYYKYKF SAEGPEDIER KRKEIVKCYT EGLLWVLLYY
FSEPPSWTWF YPFYYGPFAS DLKGLGQVKA KFKKGFPFKP IDTLMAVLPP RSAHALPKEY
QKLMTEESSS IIDFYPTDFE IDMDGKRFTW QGICKLPFIE EERLLSVTKN LDKELLGDER
DRNTEKPDQL FVRRTHNLVS QIMSLSSKES SIKIDTSSSF GVGGTIRCLD AAMSEGGDYK
LQEEHVVCML YELPDSDPHM PRLLDGVKHP SKTITKDDLT ETKLWHEYQG SAPATTTTSS
TRLQERFRRQ DNNGNGGFQN NARCTSSSTD LMHKFAGSGW GCGRGKVANP NSGERFYAPR
GIPGERVMSS SSYSAMGSTD YKRVSFHGRS VSNDKWRAVG YVSGDRAQGF KDLKISEPSQ
AWRPSARGQP ANNAFWPSRN SFGHNTNHSW QSSQLNHSHG RGRGQQQGGR GQGQQECSKR
YTPFSANDSS QAGGRSEFVP RSCVNQ
//
