ID A0A5N5KEM1_PANHP Unreviewed; 1011 AA.
AC A0A5N5KEM1;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN ORFNames=PHYPO_G00144100 {ECO:0000313|EMBL:KAB5528780.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5528780.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5528780.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5528780.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5528780.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5528780.1}.
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DR EMBL; VFJC01000025; KAB5528780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5KEM1; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000327468; Chromosome 24.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 66..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..159
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..201
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 759..956
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 407..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 111051 MW; 1E81234E987EE6C8 CRC64;
MKLLKPSWVA HNGKPIFSVD IHPDGTKFAT GGQGEDSGKV VIWNMAPVLR EEDEKNENVP
KLLCQMDNHL ACVNCVRWSN NGLYLASGGD DKLVMVWKKA AFIGPSTVFG SSSKLANVEQ
WRCVTILRNH TGDVMDVAWS PHDVWLASCS VDNTIVIWNA RKFPEMVISL SAHSGLVKGL
SWDPVGKYVA SQADDRSLKV WRTIDWQLEA NITKPFTECG GTTHVLRLSW SPDGQYLVSA
HAMNNSGPTA QIIERDGWKT NMDFVGHRKA VTVVKFNPKI FKKKPRNGSS SKPTNPYCCC
AVGSKDRSLS VWLTSLKRPL VVIHDLFDKS IMDITWTLNG LGLLVCSMDG TVAFLDFSQD
ELGDPLNEEE KNAIHQKMYG KSLAITMETQ LSSTIIENPE MLKYQQETRT SSGTLGSSTE
TPLPKLSSVV NGESLEDIRK NLLKKQVETR TADGRRRITP LCIAQLDTGD FSPALFNSVP
ILPGSSVTQL SSDSNTSLSL RVTHDPPAPS QTKPTQEAAA SSQTKSTTDN KDGSNALKSP
LLLTAASKIE PMKALDSRFT ERSKVTPGVS SSPAAVSTAP VDRMKDGSGG RTEVLKDWKA
REDSSSDSED KVVQKVAPPL AKRRNDMDAA EVVEKRKKGR PRKDSKLMMS VPQVYTQTPV
PMEKETSRVS APVAVIKLHT PAVQKSFSTQ VGSDPVVYLE VDNELCVVAG SRISQLRFCT
NGREWNMVLT SRIVVATASS DVVAVACEDR TLSVFSACGR RLVPPIMLSA PITSLHCSAH
FVMALTASAT LSVWDVQKQV ALVKNESLNS ILSGSDTVVF SMLTEHGVPV VALSNGRSYC
FSSAMETWNL IVDKQDSLVQ CADFSSCVSS HDALGCTGPL ATTQGRNLSA GRLASRLSST
PHHVQQVMTL SFLENQLSSA FILHSANEYR HWLLIYTHFL VNEGYEQRLR ELCKDLLGPV
HKSSSSAWES TVLGLRKRDL LMEVLPVVGQ NLRFQRLFTE YQDQLELLRP K
//
