ID   A0A5N5KK97_PANHP        Unreviewed;       272 AA.
AC   A0A5N5KK97;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Gap junction protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PHYPO_G00133370 {ECO:0000313|EMBL:KAB5530785.1};
OS   Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Pangasiidae; Pangasianodon.
OX   NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5530785.1, ECO:0000313|Proteomes:UP000327468};
RN   [1] {ECO:0000313|EMBL:KAB5530785.1, ECO:0000313|Proteomes:UP000327468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indonesia {ECO:0000313|EMBL:KAB5530785.1,
RC   ECO:0000313|Proteomes:UP000327468};
RC   TISSUE=Blood {ECO:0000313|EMBL:KAB5530785.1};
RA   Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA   Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA   Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA   Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA   Schartl M., Guiguen Y.;
RT   "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT   hypophthalmus.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KAB5530785.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; VFJC01000024; KAB5530785.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5N5KK97; -.
DR   OrthoDB; 5301774at2759; -.
DR   Proteomes; UP000327468; Chromosome 23.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF30; GAP JUNCTION BETA-4 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        186..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          42..75
FT                   /note="Connexin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00037"
FT   DOMAIN          141..208
FT                   /note="Gap junction protein cysteine-rich"
FT                   /evidence="ECO:0000259|SMART:SM01089"
FT   REGION          253..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   272 AA;  31421 MW;  57B9301E80E62729 CRC64;
     MNWAFLQGLV SGVNKYSTAF GRIWLSLVFI FRLLVLLVAA EKVWGDEQKE FDCNTREPGC
     HNVCYDHFFP ISPSRLWALQ LIFVTCPSLL VVLHVAYRDD RERKHQLKYG EGCAHLYTDT
     SKKRGGLWWT YLFSLIFKMA VDAIFIFLVF YIYEATFFPL LVRCQEAPCP QVTDCYISRS
     TEKRIFTIFL VVVSLICILV SLCETLYLIF KRCHECAVSH KLNKRERHFA TISSQSSKHN
     QDKMAEEAMF NKTNSHPPAK DISAPAYSLA IS
//