ID A0A5N5MUV3_PANHP Unreviewed; 2497 AA.
AC A0A5N5MUV3;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPO_G00021710 {ECO:0000313|EMBL:KAB5558830.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5558830.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5558830.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5558830.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5558830.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5558830.1}.
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DR EMBL; VFJC01000012; KAB5558830.1; -; Genomic_DNA.
DR Proteomes; UP000327468; Chromosome 11.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22831; Gal_Rha_Lectin_PKD1L2; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..2497
FT /note="Polycystic kidney disease protein 1-like 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5024318548"
FT TRANSMEM 1378..1398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1586..1606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1626..1648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1859..1882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1987..2009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2233..2253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2273..2291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2322..2342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2362..2384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2420..2449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..159
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 167..259
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 296..353
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1423..1540
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1656..1691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1665..1689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2083..2096
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2497 AA; 277618 MW; 24BD965E34E83B51 CRC64;
MDTHLLSTLL LLVILSVNAV YSEEDTEALF CLEYQKAFEG SCYEFVNLQR SFLDAQSWCE
RGGGHLAFIQ NDEIQQFLQR HLQSEQDWWL GLAPASFNLS MGSAATEGSL SWLDGSDVSY
SNWLREPELG EACGYIVKKS GFQWASTKNC SQELHFICEF ESGHALACLE HNATLQCGSG
QVIEIDDSFY GRKTLHYCRA GHSLPHTSLQ EECSWVDVVD IVSGHCHGLQ VCQAVAEVAS
FGEPCPGLGS YLSVDYHCKE GLHLLINKQA AVFDNVTLTI KWLLHPFQGN LTCTLNAGDG
HAIDPYMPEE LQSNIVHRYQ HAGVYTVTVE CSTSEWHVTA QKTITIQEPV GEFSKVVCHS
SNQTMDSENC KGLQHHALRI QVQLSAGTNI TYKIQHGLTE LAHSSEVRGI IPHNITIPRE
ALQLLGLGCH QLTLLASNGV TAPEVSASLE LCLVEPVEGL QASVAPEQDL CSDSALYVNV
SLDHGAPVDV LFLVSGDNDS FSETHQMLNG SLQMFRISSK IEGPMRVKVR TWNLFSSVEA
DAGDTLLHCQ TEDHMGDLTG DNLTITANPE SPVIGTRSIM LGVNGLNRNA NLYTFAWNCS
GTCPCNVSTQ TKGHEIRAAC LPPPYSFSVY SVTVTKTTGQ PEEQTASKCI SVSPGNDLNP
VITCSNCNPV NVSANVTLQL QCEGCQQIVW YFEDTNPVPD DLSSCYSEKG QKALMKQKEG
VSSFVIETAT LVNAQQNINV VAYGVKDGLS GSTEFTIPIL GALSTLFPTL LPDSQTTNGL
PASQPQTQAS STESIITTSN IPFSSPNTTT NTLREVSPPP FCNINPTVGD ILSPFNITCT
VAPLFCKAGP CTYCFRTSTG DYLYCGHNQT VESLFLPVGS DATNYSLVVA ITVENVEGQK
INTTLSVQVN DASIGPTVED LQSFVSKQVD QLLQLGKVTG ATLAQMFQSV SNRLNGDTTE
GQEQDAKMKL REQMLLDLGT AVNAAPLRNP SEVQKTADAV VGLTTQSEEL TSTAQLEASS
LLSNLSLSLV SLTLSEGDDK EVTRQAVTPI IQAASNILKV SASTDQQEII SENLLNAADN
VQSALLAGAS IDQEPIMVST SEISVYVNRL SPVVLQKQSF SIEYNSSASF VLPSLGPNVL
PLEEPVDVRM LSFAINPFPW RESEPINGAV ASLSITRENG SVIPVSNLSE EIEIILPRPE
AEVNSTFLDL GNYSTLVINV TMPNISLVLK LDPSEEISLQ LLLGFEHYPN NTHYKTTIQL
PQPGNSTEER YAWVLDPRDV ALDVGVYYLL VRPIVQAGVN SSNVSVFITS IAAQCKYWDE
TETNWSDYGC RVGPRTTPLL TQCLCNHLTF FGSTFFVMPN LVDVSRTAEL FATFANNPVV
VCFIGAIFLV YLMVVVWARR KDIQDTAKVK VTVLEDNDPL AEYRYLLTIS TGHRRGASTS
SQVTATLLGS EGESEPHHLT DPDKPVFERG GIDMFLLTTP FSLGELQSIR LWHDNSGKHP
AWYVNKATVQ DLETGQKWHF LCSSWLAIDV GECTLDKVFP AATEMDLKRF SNLFFMKTTK
DFQDGHIWFS VINRPPSSNF TRVQRVSCCF SLLLCTMLTS IMFWGIPTDP SEQTMDLGKI
EFTWQQVMIG IQSSIIMFPI NLLIVSIFRN VRPRERRTDQ IPKQSKTDSV KQGKTGQVSP
TQPPSPQSVH REITPDVVVK DIKRIAQSLS KALRSPMPRI DPEKMDINAL LSLVEDIICQ
QNSAGGKFYS DASKKELAIS LGAVNLHERS PEQMPKEKHS IYRQYLYKQL QNVEKELKLL
GPTRFSKPES YIQAVLQVQG MKRLLEPYLS SSSSRDQVSC SSSLGEDHRG DKKCCQKGLP
WWFVFVGWIL VAATSGVSAY FTMMYGLTYG MDRSVSWLIS MVVSFFESLF ITQPMKVLGF
AVFFALVLKT VDQEEYGDLP IEGGLSSADD PDGIRIARRD STCSFYQPPP PTDIEKMRNN
MIKEQKVFAL IREILIYVGF LWMLLLVAYG QRDPNAYYLT QHIQQSFRNG IADSMNYKDV
FTWANTTLLN SVFGRQPGFI TDGNSKLVGN ARLRQVRVHK DSCRTSSFMS RSIHDCHAPY
SWEVEDMGSY GPGWNRSTDV NLSKSFLMPW RYQTQSRLRA HPIWGGVAFY RGGGFVVDLG
PNKQNASSLL QYLFDNIWVD KYTRAIFVEF TVYNANVNLF CIVTLMFETT AVGAFQYRSD
LQSVRLYQST GGFHIFMMAS EAIYFLFILY YMFQQGKLMK QHKWEYFRSK WNLLELAIII
LSWSALCVFI KRKLLGNRDI EYYQTHKDQH ASFHETAAAD GVLGYLIAFL VLLATVKLWH
LLRLNPKLQM ITATLRRAWN DISGFIIVMT IMFLAYSIAC NLMYGWKLYS YHTLLHAAKT
IVSLQLGIFN YEEVLHYNPV LGAFVIGSCI IFMTFVVLNL FISVILVAFS EEQLHHKPSE
EEEIVDLMLM KICSLLGIKV KKNQMPDEPK ATPFAIS
//
