ID A0A5N5NJK7_PANHP Unreviewed; 1255 AA.
AC A0A5N5NJK7;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Bromodomain and PHD finger-containing protein 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPO_G00230260 {ECO:0000313|EMBL:KAB5567217.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5567217.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5567217.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5567217.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5567217.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5567217.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VFJC01000009; KAB5567217.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5NJK7; -.
DR Proteomes; UP000327468; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05512; Bromo_brd1_like; 1.
DR CDD; cd15572; PHD_BRPF; 1.
DR CDD; cd20158; PWWP_BRPF3; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF19; BROMODOMAIN AND PHD FINGER-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF00855; PWWP; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 2.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 280..330
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 334..455
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 655..725
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1126..1209
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 30..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..511
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..857
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..918
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 140843 MW; 5515860E2B96D94F CRC64;
MINRLTLDFW CFCFKDKVQA QRGCVKVSMR KPRRRGGLPG GLGARKSDAA TPRGGGARGV
AQPRSPSPYR LKVSPTRETL TYAQAQKMVE VDLDGRLHRI SIFDPLAIIT EDEMMAQDMA
ECNSNKENSE QTSATIVASP SRRSASQKGR KKDSKNASSS SQNSHRHHHT QHNSAQQHNN
TCSALPEPTF RVLESFEPID APPLPTAYYR YIEKSPEELE AEAEYDMDEE DAAWLEVVNE
KRASEGQTAV SADIFELLMD RLEKESFLES RIPQSAVDED AFCCVCLDDE CLNSNVILFC
DVCNLAVHQE CYGVPYVPEG PWLCRRCLQS PSRPVDCALC PNRGGAFKQT SDGRWAHVVC
AIWIPEVCFA NTVFLEPIEG VNNIPAARWR LTCYLCKQKG RGASIQCHRA NCYTAFHVTC
AQRAGLFMKI EPVRETTANG TTFSVKKTAF CEAHSPPEKE GSDDEENGGR VLGCRASRGM
SAYAQSPQLI KSSQSNKKGV NKKKKKGKKS PEVTSKKAST PLVTVPQIPP HRLNKVFKGI
IIQKKNYFMQ RLHNYWLLKR QSRNGVPLIR RLHSHLQAQR SADQTEPDEK VSAVREELKY
WQKLRHDLER ARLLVELIRK REKLKREQVK VHQAVMEMQL TPALMLQRST LDQLQEKDVA
RIFAEPVNLK EVPDYLEFVS QPMDFSTMRS KLEAHQYRTL SDLETDFNLM ISNCLLYNAK
DTVFYKAAVR LRELGGAILR HAQRQAHNTG LDPHTGMHLP ESPHKNDYYR CTLEDVDTLL
DPENRLHMTV EDQLKELLDK LDVVTSMRSS GARTRRIRLL RKEINNVRYR RNSHLSNGDA
KEEEQDDDED DEDKDMDAEN NLSSSSDKDD CKSTPPPTLE PSGLALSPPP GETPLDPPTL
RPMTDPKTMS PPEPLKPSTE SPDADSEVDG ASQNSRVREA PPVFSPSEGK LLNGVSNTES
PTRPVSGGVG RRTSILFRKA KNGAKLHRDK DNQLQNGESR TPQHPTAPTT TTTPLTTEAT
VPPILTPANQ RARSRSASPE EQREKTPPRS IETALTNGFK KHKDGGSDSD SSSSPILKKE
ITLPPKKSRG KPALSKVPFL ETVNGDSDYT GPVDMLSIES DAEPEPLDLV WAKCRGYPSY
PALIIDPDMP EEGVLHNGVP IPVPPADVLR LGEQRQEEAG EKLYLVLFFD NKRTWQWLPR
EKLLPLGVDD TADKLRLMEG RKTSIRKSVQ VAYDRAMIHL SRVRSDHGFI ASSYL
//
