ID A0A5N5PP97_PANHP Unreviewed; 1030 AA.
AC A0A5N5PP97;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PHYPO_G00175160 {ECO:0000313|EMBL:KAB5581395.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5581395.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5581395.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5581395.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5581395.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5581395.1}.
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DR EMBL; VFJC01000004; KAB5581395.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5PP97; -.
DR Proteomes; UP000327468; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR CDD; cd00167; SANT; 2.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; SWI_SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468}.
FT DOMAIN 170..335
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 465..616
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 817..869
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 119963 MW; 52BAACCC2B88A813 CRC64;
MSETEGSADR QREEEAEVEQ PGTTQDGASG AEEAAQDGGE QSSSPPAEKA KAEQSAGYEE
KVKTDRTNRF EYLLKQTEVF AHFIQPAAQK TPTSPLKMKP GRPRIKKDEK QNLLSAGDNR
HRRTEQEEDE ELLSESSKAA NVCTRFDESP SYVKTGKLRD YQIRGLNWLI SLYENGINGI
LADEMGLGKT LQTISLLGYM KHYRNIPGPH MVLVPKSTLY NWMNEFKRWV PSLRAVCLIG
DRDERTAFIR DTLLPGEWDV CVTSYEMLII ERAVFKKFNW RYLVIDEAHR IKNEKSKLSE
IVREFKTTNR LLLTGTPLQN NLHELWALLN FLLPDVFNSS EDFDSWFDTN NCLGDQKLVE
RLHTVLRPFL LRRIKADVEK SLLPKKEVKM YVGLSKMQRE WYTKILMKDI DILNSAGKMD
KMRLLNVLMQ LRKCCNHPYL FDGAEPGPPY TTDLHLVVNS GKMAVLDKLL PKLKEQGSRV
LIFSQMTRML DILEDYCMWR NYGYCRLDGQ TPHEERQVSI NVFNEPNSSK FLFMLSTRAG
GLGINLATAD VVIIYDSDWN PQVDLQAMDR AHRIGQKKQV RVFRFITDNT VEERIVERAE
MKLRLDSIVI QQGRLVDPNM NKLGKDEMLS IIRHGATHVF ASKESEITDE DIDVILERGE
KKTLEMKEKM SKLGEGSLRN FTMDTENSVY NFEGEDYREK KKVITNWIEP PKRERKANYA
VDAYFREALR VSEPKAPKAP RPPKQPNVQD FQFFPPRLFE LLEKEILYYR KTIGYKVPRN
PDLPNAAQVQ KEEQAKIDEA EPLNEEELEE KENLLSQGFT IWNKRDFNQF IKANEKWGRD
DIENIAREVE GKTPEEVMEY SAVFWERCNE LQDIEKIMAQ IERGEARIQR RISIKKALDS
KIGRYKAPFH QLRISYGTNK GKNYTEEEDR FLICMLHKLG FDKESVYDEL RQCIRNSPQF
RFDWFLKSRT AMELQRRCNT LITLIERENM ELEEREKAEK KKRGPRNSSA QKRKQDGTPD
GRGRKKKLKL
//
