ID A0A5N5WME2_9EURO Unreviewed; 1053 AA.
AC A0A5N5WME2;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN ORFNames=BDV29DRAFT_184514 {ECO:0000313|EMBL:KAB8068454.1};
OS Aspergillus leporis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=41062 {ECO:0000313|EMBL:KAB8068454.1, ECO:0000313|Proteomes:UP000326565};
RN [1] {ECO:0000313|EMBL:KAB8068454.1, ECO:0000313|Proteomes:UP000326565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 151.66 {ECO:0000313|EMBL:KAB8068454.1,
RC ECO:0000313|Proteomes:UP000326565};
RG DOE Joint Genome Institute;
RA Kjaerbolling I., Vesth T., Frisvad J.C., Nybo J.L., Theobald S.,
RA Kildgaard S., Isbrandt T., Kuo A., Sato A., Lyhne E.K., Kogle M.E.,
RA Wiebenga A., Kun R.S., Lubbers R.J., Makela M.R., Barry K., Chovatia M.,
RA Clum A., Daum C., Haridas S., He G., LaButti K., Lipzen A., Mondo S.,
RA Riley R., Salamov A., Simmons B.A., Magnuson J.K., Henrissat B.,
RA Mortensen U.H., Larsen T.O., Devries R.P., Grigoriev I.V., Machida M.,
RA Baker S.E., Andersen M.R.;
RT "Friends and foes A comparative genomics study of 23 Aspergillus species
RT from section Flavi.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. May promote
CC termination of transcription by RNA polymerase II.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Required for the
CC processing of nuclear mRNA and rRNA precursors. May promote termination
CC of transcription by RNA polymerase II. {ECO:0000256|ARBA:ARBA00025537}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
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DR EMBL; ML732392; KAB8068454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5WME2; -.
DR Proteomes; UP000326565; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006353; P:DNA-templated transcription termination; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR InterPro; IPR001878; Znf_CCHC.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000326565};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW Transcription {ECO:0000256|ARBA:ARBA00022472};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00022472};
KW Transcription termination {ECO:0000256|ARBA:ARBA00022472};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 270..284
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 419..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..961
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 118786 MW; C1CF1551F238E3B3 CRC64;
MGVPALFRWL SNKYPKIISS VIEETPYEVN GEQIPVDTTR PNPNGEEMDN LYLDMNGIVH
PCTHPEGKPP PANEQEMMLE IFAYTDRVVN MVRPRKLLMI AVDGVAPRAK MNQQRARRFR
SAQEAKEADE KKEEFRKSFL KKGGSKEDQA IHEEVIQKTW DSNVITPGTP FMDILAASLR
YWIAYKLNTD PAWEKLKIII SDATVPGEGE HKIMNFVRSQ RAAPEHDPNT RHVIYGLDAD
LIMLGLATHE PHFRVLREDV FFQESKARTC HLCGQAGHKA EECRGQAKVK NGEFDEKGKG
SSLKPFIWLN VSILREYLAV ELYVPHQPFP FDLERALDDW VFMCFFVGND FLPHLPSLDI
RENGIDTLIA IWRDNIPVMG GYLTKDGHVD FQKAQLILQG LAKQEDAIFR RRRQVEERKL
ANEKRRKEEA QAREERNKKR RRSSPSYETY NESPTSNRTR GGGGGGDAAA PPPGLELITP
GRGNLSREAR ELTHNMVVNR GAVYKANMAN KSAAAILKSK LMKGSQDDDE PEETNSTPDM
DETPDTTVEQ TSPSVLGKRK ANEPEGETET PGDDTDSVPK PAKNDEMPPD TVRLWDEGYA
DRYYEQKFHV DPQDKEFRHK VARAYAEGLA WVLLYYFQGC PSWTWYYPYH YAPFAADFVD
IGDMELSFDK GIPFKPFEQL MGVLPASSNH AIPEVFHDLM RNPDSEIIDF YPEDFAVDLN
GKKFAWQGVI LLPFIDEKRL LAAMEKKYPL LSEDERLRNT VGRDVLMLSD GHPLYQDLVS
NFYSKKQGDP KYKLNMHISE GLAGKVERNE TYIPHSSLVS SLEEYGMPTL EDDRSLMVNY
EIPKSSHIHK SMLLRGVKFN PPALDNADIQ ATKSKAQHSG RSFGGAPFRN GGGRGGRISY
ASDRPNDRPN DRPNPFAAHL DPSFMPPGNS GAQMMSSGWV PPVPGSGSYS RGPPPPPRGG
MSHPHHRNHY ASGQGQQQGH QQTNYGRGDY YGRGQQGHQH QGSYGNQSDQ YNGRPSSYGG
GQDYRGGGYQ RGGYHQGQGR DYSSRNPGGY GRY
//
