ID A0A5P0YQQ4_9ACTN Unreviewed; 408 AA.
AC A0A5P0YQQ4;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Bifunctional RNase H/acid phosphatase {ECO:0000313|EMBL:MQS02644.1};
GN ORFNames=FNX44_012325 {ECO:0000313|EMBL:MQS02644.1}, H3147_03470
GN {ECO:0000313|EMBL:MBB1257888.1};
OS Streptomyces alkaliterrae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2213162 {ECO:0000313|EMBL:MQS02644.1, ECO:0000313|Proteomes:UP000320857};
RN [1] {ECO:0000313|EMBL:MQS02644.1, ECO:0000313|Proteomes:UP000320857}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OF1 {ECO:0000313|EMBL:MQS02644.1,
RC ECO:0000313|Proteomes:UP000320857};
RA Golinska P.;
RT "Streptomyces sp. nov., a novel actinobacterium isolated from alkaline
RT environment.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000517765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OF8 {ECO:0000313|Proteomes:UP000517765};
RA Golinska P.;
RT "Classification of alakaliphilic streptomycetes isolated from an alkaline
RT soil next to Lonar Crater, India and a proposal for the recognition of
RT Streptomyces alkaliterrae sp. nov.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MBB1257888.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=OF8 {ECO:0000313|EMBL:MBB1257888.1};
RA Swiecimska M., Golinska P., Nouioui I., Wypij M., Rai M., Sangal V.,
RA Goodfellow M.;
RT "Streptomyces alkaliterrae sp. nov., isolated from an alkaline soil, and
RT emended descriptions of Streptomyces alkaliphilus, Streptomyces
RT calidiresistens and Streptomyces durbertensis.";
RL Syst. Appl. Microbiol. 43:0-0(0).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MQS02644.1}.
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DR EMBL; JABJXA010000012; MBB1257888.1; -; Genomic_DNA.
DR EMBL; VJYK02000105; MQS02644.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5P0YQQ4; -.
DR OrthoDB; 5296884at2; -.
DR Proteomes; UP000320857; Unassembled WGS sequence.
DR Proteomes; UP000517765; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd09279; RNase_HI_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR48100; BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED; 1.
DR PANTHER; PTHR48100:SF1; PHOSPHOGLYCERATE MUTASE PMU1-RELATED; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF13456; RVT_3; 1.
DR PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000320857}.
FT DOMAIN 1..137
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 132..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 212
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 288
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 264
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 408 AA; 43077 MW; 79197EC34BD785EE CRC64;
MARRFIVEAD GGSRGNPGPA GYGALVREAD TGQVLAETAE FIGHATNNVA EYKGLVAGLR
AARELDPEAT VRVRMDSKLV VEQMSGRWKI KHPDMRPLAK AAGEIYPPGA VTYEWIPRAQ
NKHADQLANE AMDAGRRGEQ WRPADSTAEL SAPAAAPEAP PRDAGSSDAA TPAAPAVAAA
PATSAAPEPV APPVGWGAAD LGTPTTLVLL RHGETALTPQ KRFSGSGGTD PELSEAGRRQ
ARAVADALAA RGTVQAVVTS PLRRCRETAE LAADRLGLDV RVEEDLRETD FGAWEGLTFA
EVRERHPAEL DAWLADAAVA PPGGESFAEV ARRTARARDK LLARYAGRTV LVVTHVTPVK
TLVRLALGAP PKSLFRMELA AASLSVVAYY ADGNASLRLL NETAHLRG
//
