ID A0A5Q0L8A9_9ACTN Unreviewed; 298 AA.
AC A0A5Q0L8A9;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Dihydrodipicolinate synthase family protein {ECO:0000313|EMBL:QFZ73325.1};
GN ORFNames=GFH48_08650 {ECO:0000313|EMBL:QFZ73325.1};
OS Streptomyces fagopyri.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2662397 {ECO:0000313|EMBL:QFZ73325.1, ECO:0000313|Proteomes:UP000326179};
RN [1] {ECO:0000313|EMBL:QFZ73325.1, ECO:0000313|Proteomes:UP000326179}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QMT-28 {ECO:0000313|EMBL:QFZ73325.1,
RC ECO:0000313|Proteomes:UP000326179};
RA Gao J.;
RT "A novel species.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; CP045643; QFZ73325.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5Q0L8A9; -.
DR KEGG; sfy:GFH48_08650; -.
DR Proteomes; UP000326179; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000326179}.
FT ACT_SITE 138
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 166
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 207
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 298 AA; 31771 MW; 6B6D0285AC782F46 CRC64;
MTITENRPWH GVLVATALPL NDDLSVNHDR YAAHCAWLVE NGCDGVVPNG SLGEYQVLTP
EERARVVETA VSAVGGSRVM PGVAAYGSAE ARRWAEQARD AGCESVMLLP PNAYRADERS
VLAHYAAVAE AGLPVVAYNN PIDTKVDLVP ELLAKLHAEG FVHAVKEFSG DVRRAYRIAE
LAPELDLLVG ADDVLLELAV AGAKGWVAGY PNALPAAGVE LYRAAVAGDL DSAGRLYRQL
HPLLRWDSRV EFVQAIKLSM DIVGRPGGPV RPPRVPLLPE QEAAVRAATE KAVAAGLA
//
