ID   A0A5S4G552_9ACTN        Unreviewed;       297 AA.
AC   A0A5S4G552;
DT   26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2020, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Dihydrodipicolinate synthase family protein {ECO:0000313|EMBL:TMR28135.1};
GN   ORFNames=ETD85_36895 {ECO:0000313|EMBL:TMR28135.1};
OS   Nonomuraea zeae.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1642303 {ECO:0000313|EMBL:TMR28135.1, ECO:0000313|Proteomes:UP000306628};
RN   [1] {ECO:0000313|EMBL:TMR28135.1, ECO:0000313|Proteomes:UP000306628}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100528 {ECO:0000313|EMBL:TMR28135.1,
RC   ECO:0000313|Proteomes:UP000306628};
RA   Saricaoglu S., Isik K.;
RT   "Draft genome sequence of Nonomuraea zeae DSM 100528.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DapA family.
CC       {ECO:0000256|PIRNR:PIRNR001365}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TMR28135.1}.
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DR   EMBL; VCKX01000150; TMR28135.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A5S4G552; -.
DR   OrthoDB; 9778880at2; -.
DR   Proteomes; UP000306628; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   CDD; cd00408; DHDPS-like; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002220; DapA-like.
DR   PANTHER; PTHR12128:SF74; BLL4423 PROTEIN; 1.
DR   PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR   Pfam; PF00701; DHDPS; 1.
DR   PIRSF; PIRSF001365; DHDPS; 1.
DR   PRINTS; PR00146; DHPICSNTHASE.
DR   SMART; SM01130; DHDPS; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|PIRNR:PIRNR001365};
KW   Reference proteome {ECO:0000313|Proteomes:UP000306628}.
FT   ACT_SITE        137
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   ACT_SITE        165
FT                   /note="Schiff-base intermediate with substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT   BINDING         206
FT                   /ligand="pyruvate"
FT                   /ligand_id="ChEBI:CHEBI:15361"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ   SEQUENCE   297 AA;  31680 MW;  9375E8C59BEE643B CRC64;
     MDNRSKPWHG VMVATALPLH DDLSVDFDGY AAHCRWLVEN GCDGVVPNGS LGEYQTLTPQ
     ERTKVIETAV EAVGGARVMA GAGAYGAAES RRWAEQAGAL GCGSVLLLPP NSYRADERAV
     IEHYREVAKA GVPVVAYNNP FDTKVDLTPA LLAKLHEEGL IVAVKEFTGD VRRAYELAEL
     APELDLLVGS DDVLLELGVA GAVGWVAGYP NALPAASVAL YRAALAGDLD TALPLYRKLH
     PLLRWDSKTE FVQAIKLSMD LAGRHGGPCR QPRLPLAGEQ AAVVRAATEK ALAEGLR
//