ID A0A643BUQ1_BALPH Unreviewed; 600 AA.
AC A0A643BUQ1;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=E2I00_011782 {ECO:0000313|EMBL:KAB0391739.1};
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770 {ECO:0000313|EMBL:KAB0391739.1, ECO:0000313|Proteomes:UP000437017};
RN [1] {ECO:0000313|EMBL:KAB0391739.1, ECO:0000313|Proteomes:UP000437017}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FinWhale-01 {ECO:0000313|EMBL:KAB0391739.1};
RX PubMed=31553763;
RA Westbury M.V., Petersen B., Lorenzen E.D.;
RT "Genomic analyses reveal an absence of contemporary introgressive admixture
RT between fin whales and blue whales, despite known hybrids.";
RL PLoS ONE 14:0-e0222004(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0391739.1}.
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DR EMBL; SGJD01004271; KAB0391739.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A643BUQ1; -.
DR Proteomes; UP000437017; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000437017};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..600
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5024799914"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..223
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 600 AA; 66073 MW; 98610E07E6C209FB CRC64;
MATDGGGCVA DLGNRSLLRL VSFCVLLAGL CKGNSVEKKI YIPLNKTAPC VRLLNATHQI
GCQSSVSGDT GVIHVVQKEE DLQWVLTDGP NPPYVVLLEG TLFTRNLMEK MKGRTSRIAG
LAVSLAKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIAWNSLGDG LAYEDFSFPI
FLLEDENETN VIKQCYRDHN LSQNGSAPAF PLCAMQLFSH MHAVISTVTC MRRSFIQSSF
SINPEIVCDP LSDYNVWSML KPVNTSETLE PDDKVVVAAT RETFDYIGSS RMVYDMENGK
FPVQLENIDS FVELGQVALR NSLELWMHTD PMSQKNETVQ NQVEELLTTL EKSGAGVPTV
VLRRLSRSQP LPPSSLQRFL RARNISGVVL ADHSAVFHNH YYQSIYDTAE NINVTYPEGQ
SPEEDLNFVT DAAKALAGVA TVLGRALYQL AGGTNFSDTI QADPQTFPKP WHSAALDVQV
TRLLYGFLVR ANNSWFQSIL RPDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGKV
IDLTREQCQD PSKVPTENKD FITLMVGFGV LVFSLVVTYC INAKADVLFI APREPGSVSY
//
