ID A0A643BXL2_BALPH Unreviewed; 209 AA.
AC A0A643BXL2;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 22-FEB-2023, entry version 9.
DE RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
DE Flags: Fragment;
GN ORFNames=E2I00_006089 {ECO:0000313|EMBL:KAB0392510.1};
OS Balaenoptera physalus (Fin whale) (Balaena physalus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC Balaenopteridae; Balaenoptera.
OX NCBI_TaxID=9770 {ECO:0000313|EMBL:KAB0392510.1, ECO:0000313|Proteomes:UP000437017};
RN [1] {ECO:0000313|EMBL:KAB0392510.1, ECO:0000313|Proteomes:UP000437017}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FinWhale-01 {ECO:0000313|EMBL:KAB0392510.1};
RX PubMed=31553763;
RA Westbury M.V., Petersen B., Lorenzen E.D.;
RT "Genomic analyses reveal an absence of contemporary introgressive admixture
RT between fin whales and blue whales, despite known hybrids.";
RL PLoS ONE 14:0-e0222004(2019).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000256|RuleBase:RU060637}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|RuleBase:RU060637}. Cell membrane
CC {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU060637}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU060637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB0392510.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; SGJD01003816; KAB0392510.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A643BXL2; -.
DR Proteomes; UP000437017; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003548; Claudin1.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF92; CLAUDIN-1; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
DR PRINTS; PR01377; CLAUDIN1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|RuleBase:RU060637};
KW Cell membrane {ECO:0000256|RuleBase:RU060637};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637};
KW Reference proteome {ECO:0000313|Proteomes:UP000437017};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU060637};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU060637}.
FT TRANSMEM 77..96
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT TRANSMEM 159..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU060637"
FT REGION 190..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KAB0392510.1"
SQ SEQUENCE 209 AA; 22659 MW; 6D24DC68191AA081 CRC64;
SRGFSPTNSS ANPDPDPELL QRTALPQWRI CSYAGDNIVT AQAIYEGLWM SCVSQSTGQI
QCKVFDSLLN LNSTLQATRA LMVIGILLGL VAIFVATVGM KCMKCLEDNE VQKMRMAVIG
GVIFLISGLA ILVATAWYGN RIVQEFYDPM TPVNARYEFG QALFTGWAAA SLCLLGGALL
CCSCPRKTTS YPTPRPYPKP APSSGKDYV
//