ID A0A644F3R9_GIAIC Unreviewed; 714 AA.
AC A0A644F3R9;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Cathepsin B-like cysteine proteinase {ECO:0000313|EMBL:KAE8303245.1};
GN ORFNames=GL50803_00119224 {ECO:0000313|EMBL:KAE8303245.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:KAE8303245.1, ECO:0000313|Proteomes:UP000001548};
RN [1] {ECO:0000313|EMBL:KAE8303245.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE8303245.1}.
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DR EMBL; AACB03000003; KAE8303245.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A644F3R9; -.
DR InParanoid; A0A644F3R9; -.
DR Proteomes; UP000001548; Chromosome 3.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR018466; Kre9/Knh1-like_N.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF10342; Kre9_KNH; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 1..194
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 475..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 77611 MW; 46DF317D2E6714E8 CRC64;
MVTARRCLQL NDSRLVSLED LVTCDHTKYL NIQNNGCRGG NSLASLKFGE TTGMVYDTCE
DYWNRTYPYP TETCKTVCKD KRPKDRTIKN KAPYRLSGVD AMMRDIYQNG PIAVSMYLAN
DFPSKDKKGI YSSGPNTKLG GGHAVMIVGW GEENGVPYWD CANTYGTNWG DQGYFKIKRG
SNELKIETWP GSALPIDTTP KPEPQNGTIT VEAAKTYIAG YEIAIPYKEV ATPAELQLKS
EAGAVTSLVK LTTSSGTARV TIPRDTSAGQ YYLTTSTGDA TSARFSLASY FTLAFDKTSY
QGQEGESVTL RFAAPLQVPC KLMDGASVLM ELSKGAQSCV APSSMSAGRH ALTLTTSDTV
PVLSASAVLT IEKKHNDEAV ITISNPVAGA QVTALAEGLQ ISYASTGTSA KLLLQAYCGE
RLLDVIAAGL PPSGSIEVRL PSSYGNCSAA YLRLRSETSP FAYADVGPLH VTSYGYPADD
LPAPSDKKDP VPDPEPQPDP DPEPEPEPEP IGDVPLLITE PSTQSVWVPG GAVTIRWTSN
LTASTEMTIL LYEKVGSKSY LRHTFTRSAP NTGLYADTLP ASVPSGPNYF VRMRSNSPMF
TNTSDDFEVK ASRYLVRDVP DAITVRDPLS FTIHRHGFVF PLPRRRFSVT LMQAGKEVCA
LDGVEGVAGL NTIYLDSCAE RMQELRDKQY YLKLCSQKME CTVTPTFTVL DDTH
//
