ID A0A652K5B3_9ACTN Unreviewed; 1009 AA.
AC A0A652K5B3;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Reductase {ECO:0000313|EMBL:TXS16083.1};
DE Flags: Fragment;
GN ORFNames=EAO71_35045 {ECO:0000313|EMBL:TXS16083.1};
OS Streptomyces sp. ms191.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1827978 {ECO:0000313|EMBL:TXS16083.1, ECO:0000313|Proteomes:UP000431352};
RN [1] {ECO:0000313|EMBL:TXS16083.1, ECO:0000313|Proteomes:UP000431352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ms191 {ECO:0000313|Proteomes:UP000431352};
RA Hariharan J., Choudoir M.J., Diebold P., Panke-Buisse K., Campbell A.N.,
RA Buckley D.H.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TXS16083.1}.
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DR EMBL; RDBI01000082; TXS16083.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A652K5B3; -.
DR OrthoDB; 7376058at2; -.
DR Proteomes; UP000431352; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR InterPro; IPR006963; Mopterin_OxRdtase_4Fe-4S_dom.
DR InterPro; IPR006655; Mopterin_OxRdtase_prok_CS.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF04879; Molybdop_Fe4S4; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR SMART; SM00926; Molybdop_Fe4S4; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
DR PROSITE; PS51669; 4FE4S_MOW_BIS_MGD; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS00932; MOLYBDOPTERIN_PROK_3; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000431352};
KW Transport {ECO:0000256|ARBA:ARBA00022982}.
FT DOMAIN 1..59
FT /note="4Fe-4S Mo/W bis-MGD-type"
FT /evidence="ECO:0000259|PROSITE:PS51669"
FT DOMAIN 827..965
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT REGION 970..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1009
FT /evidence="ECO:0000313|EMBL:TXS16083.1"
SQ SEQUENCE 1009 AA; 106365 MW; 732F81E9B9CF8E63 CRC64;
MRTVCSYCGV GCGMILDIGR GPDGRRTVLK ATGDKEHPAN FGRLCTKGAT TADMLAAPGR
LTTALVRERR GEAPVPVSTD RAIADTAHRL RAIVDRHGPD AVALYVSGQM SLEAQYLANK
LAKGFLGTNQ IESNSRLCMA SAGTGYKLSL GADGPPGSYQ DFEHADLFLV IGSNMADCHP
ILFLRMMERV KAGAKLIVVD PRRTATAAKA GLHLRVRPGT DLALLNGLLH LLHENGHTDP
EFIAAHTEGW EAMPAFLADY PPATVAELTG IPEEDIRTAA AWIGAAGEWT SCWTMGLNQS
THGTWNTNAL VNLHLATGAI CRPGSGPFSL TGQPNAMGGR EMGYMGPGLP GQRSVLVAED
RAFTEDLWGL APGTLREDGS GRGTVDLFRR MADGEIKACW IICTNPVASV GNRRTVIEGL
EAAELVITQD AFADTETNAY ADVILPAALW TETEGVLVNS ERNLTLASPA VDPPGEALAD
WRIIARIAGA LGHGKAFAYE SAEEIFEEIT RARNPKTGYD LTGVTYERLR DTPVQWPAAP
GGPDRNPIRY LDADGAGPVF PTPSGRAVFH ARPHLDAAEM PDDDHPFVLN TGRLQHQWHT
LTKTGRVARL NRLDPAPFVE IHPEDAERLG IAEGDAVEIT SRRGKAVLPA VVTDRVLPGC
CFAPFHWNDL FGEYLSVNAV TNDAVDPLSF QPELKVCAVA LTKTAAPGPA PRPAAAPGAA
APGGSPVPAA VQAVVVPQAA PSGVSAAFGL EPSPPPVLSA EERQYLVGFL AGLEAGAPGV
PVLPPGAPFR EEHARWVDGV LAGLYSRAPR AVPSGPGPAV PASAREIVVL WASQTGNAED
FAAATADRLV AAGHRAALAG MDETDPSALP PAADLLLITS TFGDGDAPDN GSGFWDALAG
PDTPRLDGRR YAVLAFGDSS YDDFCGHGRR LDQRLDELGA VRLAPRTDCE PDYEPSAEAW
LDQVLTSLTD VPPRTAPAPA PGPAPAAPRG DLHGVALRDA EAFGVLGVD
//
