ID   A0A652L4K7_9ACTN        Unreviewed;       991 AA.
AC   A0A652L4K7;
DT   22-APR-2020, integrated into UniProtKB/TrEMBL.
DT   22-APR-2020, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Hyaluronidase {ECO:0000313|EMBL:TXS31025.1};
GN   ORFNames=EAO71_14165 {ECO:0000313|EMBL:TXS31025.1};
OS   Streptomyces sp. ms191.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1827978 {ECO:0000313|EMBL:TXS31025.1, ECO:0000313|Proteomes:UP000431352};
RN   [1] {ECO:0000313|EMBL:TXS31025.1, ECO:0000313|Proteomes:UP000431352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ms191 {ECO:0000313|Proteomes:UP000431352};
RA   Hariharan J., Choudoir M.J., Diebold P., Panke-Buisse K., Campbell A.N.,
RA   Buckley D.H.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TXS31025.1}.
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DR   EMBL; RDBI01000040; TXS31025.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A652L4K7; -.
DR   OrthoDB; 9760892at2; -.
DR   Proteomes; UP000431352; Unassembled WGS sequence.
DR   GO; GO:0016231; F:beta-N-acetylglucosaminidase activity; IEA:UniProt.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.58.460; Hyaluronidase post-catalytic domain-like; 1.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR015882; HEX_bac_N.
DR   InterPro; IPR049019; NagJ-like_helical.
DR   InterPro; IPR011496; O-GlcNAcase_cat.
DR   PANTHER; PTHR13170; O-GLCNACASE; 1.
DR   PANTHER; PTHR13170:SF16; PROTEIN O-GLCNACASE; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02838; Glyco_hydro_20b; 1.
DR   Pfam; PF07555; NAGidase; 1.
DR   Pfam; PF21774; NagJ_C; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF140657; Hyaluronidase post-catalytic domain-like; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000431352}.
FT   DOMAIN          822..960
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          835..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          961..991
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..991
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   991 AA;  106407 MW;  203818FB70D71599 CRC64;
     MPGLAQAAPV PPTTTADDRA DARRAAAADT GVWPRPQSMT ATGPSVPLGD EVTLLADADA
     DPYALAALRE VLRSAGVRTV HTSLPGAGTV LRAGGSSGVG VSGASDALRA LRAHERTDLP
     RGGYRLATGR VQGRDTVALD GVGEDGLFHA VQTLRQLVGP QREIRGVMVR DWPGSAVRGL
     TEGFYGRPWS QEQRLAQLDF MGRTKQNRFL YAPGDDPYRQ TLWREPYPAE QRAAFRALAE
     RARANHVTLA WAVAPAQSMC LASDDDVRAL NRKIDAMWAL GVRSFQLQFQ DVSYSEWHCS
     KDADVFGRGP EAAAAAHARV TSAVARHLAE RHPGAEPLTL MPTEYYQDGR TDYRAALAAA
     LDDRVQVAWT GVGVVPRTIT GRELAGARAT FRHPLVTMDN YPVNDYAQDR LFLGAYQGRE
     PAVAAGSAAF LANAMEQATA SRVPLFTAAD YAWNPKGYRP QESWRAAVDD LAGPDAAARE
     ALWALAGNDA SSLLDPAGES AYLKPLMAAF WSSRTAGSPA VREKAARELR AAFTVMREAP
     RRLAATADGA LAEEARPWLA RLSQYGLAGE TAVDMLLAQT RGDGTAAWQA SLRLEPMRAS
     LGQAGQVTVG KGVLDPFLTR AATESAAWTG ADRERRTGRR AEREQSAYVL RLDRARPVET
     LTVMTEPGSG EGARVEAYVT GEGWRPLGPL SPSGWTQADA KGLRAEAVRI AWTGAAPEVR
     SLVPWFADEP HADLELARGE TDAEIGGTAQ RVDVHLVAQR AGEVRGALTA RAPKGIAVRL
     PKEVLVPRGT RTTVPLEVSV APDVPAGSYQ VPVSFAGEER VLTVRAFPRT AGPDLARTAT
     ASSSGDETPD FPAASALDGD PATRWSSPAE DGAWWQLELA QPTRIGQVVL HWQDAYASRY
     RIQVSADGRT WRTAATVADG RGGREAVRMD AADTRFLRVQ GDARATPYGY SLWTVETYAV
     APPETPAPPA QQPSQQPEQP QATQEPQTPQ E
//