ID A0A653CQ71_CALMS Unreviewed; 447 AA.
AC A0A653CQ71;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Cathepsin L {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=CALMAC_LOCUS10951 {ECO:0000313|EMBL:VEN50058.1};
OS Callosobruchus maculatus (Southern cowpea weevil) (Pulse bruchid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Chrysomeloidea; Chrysomelidae; Bruchinae; Bruchini; Callosobruchus.
OX NCBI_TaxID=64391 {ECO:0000313|EMBL:VEN50058.1, ECO:0000313|Proteomes:UP000410492};
RN [1] {ECO:0000313|EMBL:VEN50058.1, ECO:0000313|Proteomes:UP000410492}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sayadi A.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CAACVG010008496; VEN50058.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A653CQ71; -.
DR Proteomes; UP000410492; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF971; CATHEPSIN L-RELATED; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 2.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 2.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 2.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000410492};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 23..70
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 94..154
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 181..392
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:VEN50058.1"
FT NON_TER 447
FT /evidence="ECO:0000313|EMBL:VEN50058.1"
SQ SEQUENCE 447 AA; 50123 MW; 61FD5BF7E4EE58C5 CRC64;
WKVLDKVIHG FSNTPKGFPF CLKVDHGKTY RSLREEQARF SVFQSNLRTI EQHNAKYEAG
EETYYLKFNM KVFVAVALFL VAVQVQAGSD QELWTQFKVD HGKTYRSLRE EQARFSVFQS
NLRTIEQHNA KYEAGEETYY LKVTQFADMT PEEFKEFLSL GEKTKPDLNH PVYEPDMTVA
APNSVDWRQK GAVLEVKNQG QCGSCWSFSA TGCLEGQNAI KHGQKISLSE QNLMDCSGGY
GNNGCDGGLM TNAFFYVHDH GINSEAAYPY EGKVKNCRFD SSKSIVQVDG VYKVNEDEEA
LKQVIALEGP VSVGVDASGF SLYGGGVFNP RSCSSSSINH GVLAVGYGTE GNTDYWIVKN
SWGPGWGESG YIKMIRNHNN RCGIVTLASI VTLKSDEFRD QLIQKLIEYV KKTLEIFRVG
KELGENGTEG RNGFAENFDN FEHLENT
//
